840074C

Avanti

Soy PA

L-α-phosphatidic acid (Soy) (sodium salt), chloroform

CAS Number:
NACRES:
NA.25

assay

>99% (TLC)

packaging

pkg of 1 × 2.5 mL (840074C-25mg)

manufacturer/tradename

Avanti Polar Lipids 840074C

concentration

10 mg/mL (840074C-25mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidic acid (PA) is a diacyl-glycerophospholipid, with two fatty acids and a phosphate group that are covalently attached to a glycerol molecule through ester linkages. PA is rich in soy lecithin. PA is produced endogenously by the hydrolytic action of the enzyme phospholipase D. It is also produced through phosphorylation of diacyl glycerol (DAG) by diacylglycerol kinases (DGKs).

Application

Soy PA is suitable for use in validation of PA probe.

Biochem/physiol Actions

Phosphatidic acid (PA) is present in biomembranes. It is the precursor for other phospholipids and acts as a signaling molecule. PA is implicated in NAPDH oxidase (NOX) activity.

Packaging

5 mL Clear Glass Sealed Ampule (840074C-25mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

hazcat

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

storage_class_code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK Germany

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificate of Analysis

Certificate of Origin

The mitotic and metabolic effects of phosphatidic acid in the primary muscle cells of turbot (Scophthalmus maximus)
Wang T, et al.
Frontiers in Endocrinology, 9 (2018)
Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation
Schlam D, et al.
Journal of biological and chemical chronicles, 288(32), 23090-23104 (2013)
Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy
Joy JM, et al.
Nutrition, 11(1), 29-29 (2014)
Daniel Schlam et al.
The Journal of biological chemistry, 288(32), 23090-23104 (2013-07-03)
It is commonly assumed that all phagosomes have identical molecular composition. This assumption has remained largely unchallenged due to a paucity of methods to distinguish individual phagosomes. We devised an assay that extends the utility of nitro blue tetrazolium for...
Michal Bohdanowicz et al.
Molecular biology of the cell, 24(11), 1700-1712 (2013-04-12)
Macrophages and dendritic cells continuously survey their environment in search of foreign particles and soluble antigens. Such surveillance involves the ongoing extension of actin-rich protrusions and the consequent formation of phagosomes and macropinosomes. The signals inducing this constitutive cytoskeletal remodeling...

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