840074P

Avanti

Soy PA

L-α-phosphatidic acid (Soy) (sodium salt), powder

CAS Number:
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (840074P-25mg)

manufacturer/tradename

Avanti Polar Lipids 840074P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O)=O)(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

General description

Phosphatidic acid (PA) is a diacyl-glycerophospholipid, with two fatty acids and a phosphate group that are covalently attached to a glycerol molecule through ester linkages. PA is synthesized by the activity of the endogenous enzyme phospholipase D or by supplementation with soy lecithin.

Application

Soy PA is suitable for use to study its effect on cell proliferation, nutrient sensing and to examine metabolic pathways in primary muscle cells of turbot (Scophthalmus maximus).

Biochem/physiol Actions

Phosphatidic acid (PA) is a prime glycerophospholipid present in the biomembrane and is a precursor for phosphatidylcholine or phosphatidylserine. It has different functions in the cells like influencing the membrane curvature and signaling.

Packaging

5 mL Clear Glass Sealed Ampule (840074P-25mg)

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificate of Analysis

Certificate of Origin

The mitotic and metabolic effects of phosphatidic acid in the primary muscle cells of turbot (Scophthalmus maximus)
Wang T, et al.
Frontiers in Endocrinology, 9 (2018)
Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy
Joy JM, et al.
Nutrition, 11(1), 29-29 (2014)
Daniel Schlam et al.
The Journal of biological chemistry, 288(32), 23090-23104 (2013-07-03)
It is commonly assumed that all phagosomes have identical molecular composition. This assumption has remained largely unchallenged due to a paucity of methods to distinguish individual phagosomes. We devised an assay that extends the utility of nitro blue tetrazolium for...
Michal Bohdanowicz et al.
Molecular biology of the cell, 24(11), 1700-1712 (2013-04-12)
Macrophages and dendritic cells continuously survey their environment in search of foreign particles and soluble antigens. Such surveillance involves the ongoing extension of actin-rich protrusions and the consequent formation of phagosomes and macropinosomes. The signals inducing this constitutive cytoskeletal remodeling...
Chi-Lun Chang et al.
The Journal of biological chemistry, 290(23), 14289-14301 (2015-04-19)
Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) at the plasma membrane (PM) constitutively controls many cellular functions, and its hydrolysis via receptor stimulation governs cell signaling. The PI transfer protein Nir2 is essential for replenishing PM PIP2 following receptor-induced hydrolysis, but key mechanistic...

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