840101C

Avanti

Egg PA

L-α-phosphatidic acid (Egg, Chicken) (sodium salt), chloroform

CAS Number:
NACRES:
NA.25

assay

>99% (TLC)

packaging

pkg of 1 × 2.5 mL (840101C-25mg)

manufacturer/tradename

Avanti Polar Lipids 840101C

concentration

10 mg/mL (840101C-25mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidic acid (PA) is synthesized by the action of phospholipase D (PLD) on glycerophospholipids and by phosphorylation of diacylglycerol (DAG) by DAG kinase.

Application

Egg PA has been used in SEIPEN binding studies. It is suitable for use in the preparation of liposomes and to deduce different species of phosphatidic acid from egg by liquid chromatography-mass spectroscopy (LC-MS) and least squares spectral resolution (LSSR) analysis.

Biochem/physiol Actions

Phosphatidic acid (PA) contributes to membrane biogenesis by involving in the synthesis of glycerophospholipids like phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine. PA is implicated in cell signaling.

Packaging

5 mL Clear Glass Sealed Ampule (840101C-25mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

hazcat

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

storage_class_code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK Germany

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificate of Analysis

Certificate of Origin

Extension of least squares spectral resolution algorithm to high-resolution lipidomics data
Zeng YX, et al.
Analytica Chimica Acta, 914(8), 35-46 (2016)
The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans
Klopfenstein DR and Vale RD
Molecular Biology of the Cell, 15(8), 3729-3739 (2004)
Brain Lipids in Synaptic Function and Neurological Disease: Clues to Innovative Therapeutic Strategies for Brain Disorders (2015)
Xianping Li et al.
Infection and immunity, 80(1), 429-440 (2011-11-16)
Aspergillus fumigatus is the most prevalent airborne fungal pathogen that induces serious infections in immunocompromised patients. Phospholipases are key enzymes in pathogenic fungi that cleave host phospholipids, resulting in membrane destabilization and host cell penetration. However, knowledge of the impact...
Meygal Kahana et al.
Molecular psychiatry (2020-05-07)
Delivery of drugs into the brain is poor due to the blood brain barrier (BBB). This study describes the development of a novel liposome-based brain-targeting drug delivery system. The liposomes incorporate a diacylglycerol moiety coupled through a linker to a...

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