840101P

Avanti

Egg PA

L-α-phosphatidic acid (Egg, Chicken) (sodium salt), powder

CAS Number:
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (840101P-1g)
pkg of 2 × 100 mg (840101P-200mg)
pkg of 5 × 100 mg (840101P-500mg)
pkg of 1 × 25 mg (840101P-25mg)

manufacturer/tradename

Avanti Polar Lipids 840101P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

General description

Phosphatidic acid is a simple and basic glycerophospholipid. It is an ester of glycerol with two long chain fatty acids at C1 and C2 position and phosphoric acid at C3 position. PA is synthesized by the hydrolytic action of phospholipase D on glycerophospholipids.

Application

Egg PA is suitable for use:
  • in the preparation of reconstituted high density lipoprotein (rHDL) along with serum amyloid A (SAA)
  • as negatively charged lipid in the preparation of giant unilamellar vesicles
  • in the preparation of liposomes

Biochem/physiol Actions

Phosphatidic acid (PA) is involved in the synthesis of phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine and cardiolipin. PA functions as a signaling molecule.

Packaging

5 mL Clear Glass Sealed Ampule (840101P-200mg)
5 mL Clear Glass Sealed Ampule (840101P-500mg)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (840101P-1g)
5 mL Clear Glass Sealed Ampule (840101P-25mg)

storage_class_code

13 - Non Combustible Solids

Certificate of Analysis

Certificate of Origin

Hepatitis B virus X protein induces size-selective membrane permeabilization through interaction with cardiolipin
You DG, et al.
Biochimica et Biophysica Acta - Biomembranes, 1861(4), 729-737 (2019)
Muscle and Exercise Physiology (2018)
Biochemistry of Lipids, Lipoproteins and Membranes (1996)
Effects of lipid composition on the structural properties of human serum amyloid A in reconstituted high-density lipoprotein particles
Takase H, et al.
Chemistry and Physics of Lipids, 221, 8-14 (2019)
Xianping Li et al.
Infection and immunity, 80(1), 429-440 (2011-11-16)
Aspergillus fumigatus is the most prevalent airborne fungal pathogen that induces serious infections in immunocompromised patients. Phospholipases are key enzymes in pathogenic fungi that cleave host phospholipids, resulting in membrane destabilization and host cell penetration. However, knowledge of the impact...

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