841118C

Avanti

Egg Trans PE

L-α-phosphatidylethanolamine, transphosphatidylated (Egg, Chicken), chloroform

Synonym(s):
L-a-Phosphatidylethanolamine Transphosphatidylated (prepared from Egg PC)
CAS Number:
NACRES:
NA.25

assay

>99% (TLC)

packaging

pkg of 1 × 2.5 mL (841118C-25mg)

manufacturer/tradename

Avanti Polar Lipids 841118C

concentration

10 mg/mL (841118C-25mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O

General description

Phosphatidylethanolamine (PE) is a phospholipid found in all living organism. The egg yolk contains high levels of unsaturated PE which accounts to 83.10%. The phosphatidylethanolamine (PE) headgroup is a zwitterion, with a negatively charged phosphate group and positively charged free amine group.

Application

Egg Trans PE is suitable for use:
  • in the incubation of platelets for phospholipid enrichment and quantification by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
  • in the synthesis of isoketals-phosphatidylethanolamine (IsoK-PE)
  • in the preparation of phospholipid vesicles for factor X activation studies

Biochem/physiol Actions

Phosphatidylethanolamine (PE) along with other phospholipids forms the backbone of biological membranes. PE is known to regulate autophagy. The autophagic membranes possesses PE with high degree of unsaturation. Egg yolk PE has high radical scavenging activity owing to antioxidant potential.

Packaging

5 mL Clear Glass Sealed Ampule (841118C-25mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

hazcat

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

storage_class_code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK Germany

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificate of Analysis

Certificate of Origin

C Blake Sullivan et al.
Journal of lipid research, 51(5), 999-1009 (2009-12-08)
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are gamma-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditions including cardiovascular disease. IsoKs can induce ion channel...
The
The Membranes of Cells, 22(3) (2016)
Mark L Bannister et al.
Circulation research, 116(8), 1324-1335 (2015-02-05)
Flecainide, a class 1c antiarrhythmic, has emerged as an effective therapy in preventing arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) refractory to β-adrenergic receptor blockade. It has been proposed that the clinical efficacy of flecainide in CPVT is...
Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake
Bloem E, et al.
Journal of biological and chemical chronicles, 288(41), 29670-29679 (2013)
Isoketals form cytotoxic phosphatidylethanolamine adducts in cells
Sullivan CB, et al.
Journal of Lipid Research, 51(5), 999-1009 (2010)

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