850312P

Avanti

DOCPe

2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethyl phosphate, powder

Empirical Formula (Hill Notation):
C45H86NO8P
CAS Number:
Molecular Weight:
800.14
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 200 mg (850312P-200mg)
pkg of 1 × 25 mg (850312P-25mg)

manufacturer/tradename

Avanti Polar Lipids 850312P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(CCOP([O-])(OCC)=O)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

General description

Inverse-phosphocholine lipids, a remix of a common phospholipid, contain headgroups with an inverted charge orientation relative to phosphocholine (PC) lipids. The iPC lipid headgroup has a quaternary amine adjacent to the bilayer interface and a phosphate that extends into the aqueous phase. Therefore iPC lipids afford a unique opportunity to investigate the biophysical and bioactivity-related ramifications of a charge inversion at the bilayer surface.
2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethylphosphate (DOCPe) is a neutrally charged lipid.

Application

DOCPe is suitable for liposomes preparation.

Packaging

20 mL Clear Glass Screw Cap Vial (850312P-200mg)
5 mL Clear Glass Sealed Ampule (850312P-25mg)

storage_class_code

13 - Non Combustible Solids

Certificate of Analysis

Certificate of Origin

Charge and Coordination Directed Liposome Fusion onto SiO2 and TiO2 Nanoparticles
Wang X, et al.
Langmuir, 35(5), 1672-1681 (2018)
Emily K Perttu et al.
Journal of the American Chemical Society, 134(10), 4485-4488 (2012-03-01)
Zwitterionic inverse-phosphocholine (iPC) lipids contain headgroups with an inverted charge orientation relative to phosphocholine (PC) lipids. The iPC lipid headgroup has a quaternary amine adjacent to the bilayer interface and a phosphate that extends into the aqueous phase. Neutral iPC...
Yibo Liu et al.
Langmuir : the ACS journal of surfaces and colloids, 34(32), 9337-9348 (2018-03-13)
Phospholipids are a major component of the cell membrane. In most natural phospholipids, the phosphate acts as a bridge, connecting the other portion of the polar headgroup with the hydrophobic tails. Such bridging phosphate is chemically quite inert. Synthetic lipids...
Feng Wang et al.
Journal of the American Chemical Society, 137(36), 11736-11742 (2015-08-25)
Zwitterionic phosphocholine (PC) lipids are highly biocompatible, representing a major component of the cell membrane. A simple mixing of PC liposomes and silica (SiO2) surface results in liposome fusion with the surface and formation of supported lipid bilayers. However, the...

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