All Photos(2)

855810P

Avanti

26:0 Lyso PC

1-hexacosanoyl-2-hydroxy-sn-glycero-3-phosphocholine, powder

Synonym(s):
1-hexacosanoyl-sn-glycero-3-phosphocholine; PC(26:0/0:0)
Empirical Formula (Hill Notation):
C34H70NO7P
CAS Number:
Molecular Weight:
635.90
NACRES:
NA.25

assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

powder

packaging

pkg of 1 × 10 mg (855810P-10mg)
pkg of 1 × 25 mg (855810P-25mg)
pkg of 1 × 5 mg (855810P-5mg)

manufacturer/tradename

Avanti Polar Lipids 855810P

shipped in

dry ice

storage temp.

−20°C

General description

Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid, which has a choline group at its polar head. It is produced by pathological response.

Application

26:0 Lyso PC has been used as an internal standard for C26:0-lysophosphatidylcholine (LPC) extraction.

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) induces many second messengers including, protein kinase C, extracellular-signal-regulated kinases and protein tyrosine kinases. It alters various biological functions in different cell types, including endothelial cells, smooth muscle cells, monocytes, macrophages and T-cells. LPC is linked to atherosclerosis and inflammatory diseases.

Packaging

5 mL Amber Glass Screw Cap Vial (855810P-25mg)
5 mL Amber Glass Screw Cap Vial (855810P-10mg)
5 mL Amber Glass Screw Cap Vial (855810P-5mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

Certificate of Origin

Xinying Hong et al.
Genetics in medicine : official journal of the American College of Medical Genetics (2020-04-21)
To develop a multiplexed assay for the newborn screening of lysosomal storage disorders and additional inborn errors in a flexible, comprehensive, and affordable manner to keep up with the expansion of the newborn screening panel. Ultraperformance liquid chromatography-tandem mass spectrometry
A thyroid hormone-based strategy for correcting the biochemical abnormality in X-linked adrenoleukodystrophy
Hartley MD, et al.
Endocrinology, 158(5), 1328-1338 (2017)
Analysis of phospholipid species in rat peritoneal surface layer by liquid chromatography/electrospray ionization ion-trap mass spectrometry
Gao F, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1761(7), 667-676 (2006)
Kelsey B Law et al.
Autophagy, 13(5), 868-884 (2017-05-20)
Peroxisome biogenesis disorders (PBDs) are metabolic disorders caused by the loss of peroxisomes. The majority of PBDs result from mutation in one of 3 genes that encode for the peroxisomal AAA ATPase complex (AAA-complex) required for cycling PEX5 for peroxisomal
Role of lysophosphatidylcholine (LPC) in atherosclerosis
Matsumoto T, et al.
Current Medicinal Chemistry, 14(30), 3209-3220 (2007)

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