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860020P

Avanti

Egg Sphingosine

D-erythro-Sphingosine (Egg, Chicken), powder

Synonym(s):
Sphingosine 2S, 3R; D-erythro-sphingosine; (2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol; (2S,3R,4E)-2-amino-1,3-octadec-4-enediol
CAS Number:
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860020P-5mg)

shipped in

dry ice

storage temp.

−20°C

General description

Egg sphingosine is a central metabolite, which arises from the de novo synthesis of cellular sphingolipids. It modulates growth, differentiation, survival and cell death. Egg sphingosine functions as a pharmacological inhibitor of protein kinase C in human platelets. It is also implicated in inhibiting platelet aggregation in cells.

Application

Egg sphingosine has been used to study protein-lipid interaction.

Packaging

5 mL Amber Glass Screw Cap Vial (860020P-5mg)

Storage Class Code

13 - Non Combustible Solids

WGK Germany

WGK 3

Certificate of Analysis

Certificate of Origin

Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets
Khan WA, et al.
The Biochemical Journal, 278(2), 387-392 (1991)
Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine
Grimm C, et al.
Molecular Pharmacology, 67(3), 798-805 (2005)
Mathias J Gerl et al.
PloS one, 11(4), e0153009-e0153009 (2016-04-23)
Cell membranes contain hundreds to thousands of individual lipid species that are of structural importance but also specifically interact with proteins. Due to their highly controlled synthesis and role in signaling events sphingolipids are an intensely studied class of lipids....

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