Brain sphingosine is a central metabolite, which is produced from the de novo synthesis of cellular sphingolipids. It is involved in growth, differentiation, survival and cell death. D-erythro-Sphingosine acts as a pharmacological inhibitor of protein kinase C in human platelets. It prevents platelet aggregation in cells.
Brain sphingosine has been used as a standard in the fluorimetric determination of sphingosine in porcine enterocyte monosialogangliosides.
Journal of virology, 72(11), 9079-9091 (1998-10-10)
A ganglioside fraction isolated from pooled intestines from newborn to 4-week-old piglets, which we previously partially characterized and showed to specifically inhibit the binding of porcine rotavirus (OSU strain) to host cells (M. D. Rolsma, H. B. Gelberg, and M....
Structure and function of a ganglioside receptor for porcine rotavirus
Rolsma MD, et al.
Journal of Virology, 72(11), 9079-9091 (1998)
Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets
Khan WA, et al.
The Biochemical Journal, 278(2), 387-392 (1991)
Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine
Grimm C, et al.
Molecular Pharmacology, 67(3), 798-805 (2005)
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