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860526P

Avanti

1-O-Acyl-Ceramide

Avanti Polar Lipids 860526P, powder

Synonym(s):
1-oleoyl-N-heptadecanoyl-D-erythro-sphingosine
Empirical Formula (Hill Notation):
C53H101NO4
CAS Number:
Molecular Weight:
816.37
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (860526P-5mg)

manufacturer/tradename

Avanti Polar Lipids 860526P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

General description

1-O-Acyl-Ceramide is an epidermal ceramide present in mouse and human epidermis. It comprises long chain fatty acids in 1-O-position and is synthesized in the endoplasmic reticulum-related sites.

Application

1-O-Acyl-Ceramide is suitable for use as a lipid standard in
  • high performance thin layer chromatography (HPTLC)
  • in mass and nuclear magnetic resonance spectroscopy for the quantification of lipids isolated from vernix caseosa skin cream
  • in liquid chromatography-tandem mass spectrometry for the quantification of 1-O-Acyl ceramides from liver samples

Biochem/physiol Actions

1-O-Acyl-Ceramide functions in maintaining water barrier homeostasis. Deficiency of the glucosylceramide synthase enzyme leads to the accumulation of O-acylceramides. Treatment of human monoclonal antibody, REMD 2.59 leads to the accumulation of 1-O-acyl-ceramides in soleus muscle and depletion in liver.

Packaging

5 mL Amber Glass Screw Cap Vial (860526P-5mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More documents

Quotes and Ordering

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania
Trinconi CT, et al.
International Journal for Parasitology, Drugs and Drug Resistance, 8(3), 475-487 (2018)
Nonhydroxylated 1-O-acylceramides in vernix caseosa
Harazim E, et al.
Journal of Lipid Research, 59(11), 2164-2173 (2018)
Glucagon receptor antagonism improves glucose metabolism and cardiac function by promoting AMP-mediated protein kinase in diabetic mice
Sharma AX, et al.
Testing, 22(7), 1760-1773 (2018)
1-O-acylceramides are natural components of human and mouse epidermis
Rabionet M, et al.
Journal of Lipid Research, 54(12), 3312-3321 (2013)
Aline Bayerle et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(9), 158741-158741 (2020-06-01)
Except for epidermis and liver, little is known about endogenous expression of 1-O-acylceramides (1-OACs) in mammalian tissue. Therefore, we screened several organs (brain, lung, liver, spleen, lymph nodes, heart, kidney, thymus, small intestine, and colon) from mice for the presence

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