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860634P

Avanti

C16 Dihydroceramide (d18:0/16:0)

Avanti Polar Lipids 860634P, powder

Synonym(s):
N-palmitoyl-D-erythro-sphinganine
Empirical Formula (Hill Notation):
C34H69NO3
CAS Number:
Molecular Weight:
539.92
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (860634P-10mg)
pkg of 1 × 5 mg (860634P-5mg)

manufacturer/tradename

Avanti Polar Lipids 860634P

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

Application

C16 Dihydroceramide (d18:0/16:0) is suitable for use to study the potential relevance of the changes observed in the sphingolipid composition of autophagosomes and autolysosomes in tetrahydrocannabinol (THC) treated cells or to destabilize biological membranes.

Biochem/physiol Actions

Dihydroceramide acts as a precursor for ceramide synthesis. It has an ability to induce autophagy in the perinuclear region. Dihydroceramide affects autophagic flux and enhances the formation lipid droplets. Accumulation of C16-dihydroceramides might lead to liver injury.

Packaging

5 mL Amber Glass Screw Cap Vial (860634P-10mg)
5 mL Amber Glass Screw Cap Vial (860634P-5mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

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Certificate of Origin

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More Documents

Quotes and Ordering

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Hernandez-Tiedra S, et al.
Autophagy, 12(11), 2213-2229 (2016)
Md Abdullah Al Sazzad et al.
Langmuir : the ACS journal of surfaces and colloids, 32(23), 5973-5980 (2016-05-25)
To better understand the interactions of saturated ceramides with unsaturated glycerophospholipids in bilayer membranes, we measured how palmitoyl ceramide (PCer) and dihydroceramide (dihydro-PCer, lacking the trans 4 double bond of the sphingoid base of ceramide) can interact with phosphatidylcholines (PCs)
Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model
Lee Ah young, et al.
Biochemical and biophysical research communications, 494(3-4), 460-469 (2017)
Sonia Hernández-Tiedra et al.
Autophagy, 12(11), 2213-2229 (2016-11-02)
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main

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