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860675P

Avanti

Sphinganine-1-Phosphate (d20:0)

D-erythro-sphinganine-1-phosphate (C20 base), powder

Empirical Formula (Hill Notation):
C20H44NO5P
CAS Number:
Molecular Weight:
409.54
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (860675P-1mg)

manufacturer/tradename

Avanti Polar Lipids 860675P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](CCCCCCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O

General description

Sphinganine-1-Phosphate is a phosphorylated derivative of C20 base sphinganine.

Biochem/physiol Actions

Exogenous sphinganine-1-phosphate activates sphingosine-1-phosphate receptor 1 (S1P1). It exhibits protective effects against hepatic and renal ischemia and reperfusion (IR). Sphingosine-1 phosphate and sphinganine-1-phosphate are bioactive lipid mediators. Sphinganine-1-phosphate acts opposite to sphingosine-1 phosphate activities. Increased concentration of sphinganine-1-phosphate acts as a potential biomarker for fumonisin exposure and toxicity in mice.

Packaging

5 mL Amber Glass Screw Cap Vial (860675P-1mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Certificate of Analysis

Certificate of Origin

Dong-Hyun Kim et al.
Journal of toxicology and environmental health. Part A, 69(23), 2071-2082 (2006-10-25)
Fumonisins are specific inhibitors of ceramide synthase in sphingolipid metabolism. An alteration in sphingolipid metabolism as a result of fumonisin B1 (FB1) exposure is related to cell death, and sphinganine/sphingosine ratio has been used as an indicator of fumonisin exposure
Shizhong Bu et al.
Arthritis and rheumatism, 62(7), 2117-2126 (2010-03-24)
Previous studies have revealed a phosphatase and tensin homolog (PTEN)-dependent interaction between the sphingolipid agonist dihydrosphingosine 1-phosphate (dhS1P) and the transforming growth factor beta/Smad3 signaling pathway. This study was undertaken to examine responses of systemic sclerosis (SSc) fibroblasts to sphingosine
Sang Won Park et al.
Laboratory investigation; a journal of technical methods and pathology, 90(8), 1209-1224 (2010-05-12)
Liver failure due to ischemia and reperfusion (IR) and subsequent acute kidney injury are significant clinical problems. We showed previously that liver IR selectively reduced plasma sphinganine-1-phosphate levels without affecting sphingosine-1-phosphate (S1P) levels. Furthermore, exogenous sphinganine-1-phosphate protected against both liver

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