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860692P

Avanti

C16:0 Ceramide (d18:2(4E,8Z)/16:0)

N-palmitoyl-D-erythro-sphingosine (d18:2(4E,8Z) base), powder

Empirical Formula (Hill Notation):
C34H65NO3
Molecular Weight:
535.88
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (860692P-1mg)

manufacturer/tradename

Avanti Polar Lipids 860692P

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@@](NC(CCCCCCCCCCCCCCC)=O)([H])[C@]([H])(O)/C=C/CC/C=C\CCCCCCCCC

General description

C16:0 Ceramide (d18:2(4E,8Z)/16:0) or N-palmitoyl-D-erythro-sphingosine (d18:2(4E,8Z) base) is a long chain ceramide derived from sphingosine containing two double bonds with palmitic acid. C16:0 Ceramide synthesis is catalyzed by the enzyme ceramide synthase 6 (CerS6).

Biochem/physiol Actions

C16:0-ceramide facilitates obesity-related insulin resistance. It exhibits pro-apoptotic function. Elevated levels of C16:0-ceramide has been observed in adipose tissue of obese patients.

Packaging

5 mL Amber Glass Screw Cap Vial (860692P-1mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificate of Analysis

Certificate of Origin

Sarah M Turpin et al.
Cell metabolism, 20(4), 678-686 (2014-10-09)
Ceramides increase during obesity and promote insulin resistance. Ceramides vary in acyl-chain lengths from C14:0 to C30:0 and are synthesized by six ceramide synthase enzymes (CerS1-6). It remains unresolved whether obesity-associated alterations of specific CerSs and their defined acyl-chain length
Timothy Hla et al.
Cell metabolism, 20(5), 703-705 (2014-12-03)
A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related

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