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870865P

Avanti

BMP22

4-pentadecylbenzylphosphonic acid, powder

Empirical Formula (Hill Notation):
C22H39O3P
Molecular Weight:
382.52

form

powder

packaging

pkg of 1 × 1 mg (870865P-1mg)
pkg of 1 × 5 mg (870865P-5mg)

manufacturer/tradename

Avanti Polar Lipids

technique(s)

thin layer chromatography (TLC): 99%

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCC1=CC=C(CP(O)(O)=O)C=C1

General description

BMP (bis(monoacylglycerol)phosphate) is synthesized from phosphatidylglycerol (PG) in alveolar macrophages. BMP is a unique phospholipid having a glycerol phosphate ester at sn-1 position rather than sn-3 and has one acyl group attached to each of the glycerol moieties. The acyl groups of BMP is rich in polyunsaturated species.

Biochem/physiol Actions

BMP (bis(monoacylglycerol)phosphate) (BMP) is found in the retinal pigment epithelium of healthy human retina. BMP lipids regulates cholesterol level in endosomes. It is implicated in endosomal/lysosomal storage diseases like Niemann-Pick and neuronal ceroid lipofuscinosis diseases. BMP22/4PBPA is a small molecule inhibitor of autotaxin (ATX). 4PBPA has relatively a longer half-life and also reduces the lysophosphatidic acid concentration in plasma. BMP22 is implicated in reducing the bone erosion and systemic bone loss.

Packaging

5ML Glass Amber Screw Cap Vial (870865P-5MG)
5ML Glass Amber Screw Cap Vial (870865P-1MG)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
Gotoh M, et al.
Biochemical Society Transactions, 40(1), 31-36 (2012)
Bis (monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas
Anderson DMG, et al.
Scientific Reports, 7(1), 17352-17352 (2017)
Osteoclast-derived Autotaxin, a distinguishing factor for inflammatory bone loss
Flammier S, et al.
Arthritis and Rheumatism (2019)
Transacylase formation of bis (monoacylglycerol) phosphate
Heravi J and Waite M
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1437(3), 277-286 (1999)

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