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880134P

Avanti

PMA

Polymethacrylate Copolymer (N-C4-52-6.9), powder

NACRES:
NA.25

form

powder

packaging

pkg of 1 × 100 mg (880134P-100mg)
pkg of 1 × 500 mg (880134P-500mg)

manufacturer/tradename

Avanti Polar Lipids (880134P)

application(s)

NMR: 99%

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[N+](C)(C)CCOC(C(C)(CC(C)([H])C(OCCCC)=O)CSCCC(OC)=O)=O.[Cl-]

General description

PMA (polymethacrylate) random copolymer is amphiphilic and consists of hydrophobic and hydrophilic sidechains.

Biochem/physiol Actions

PMA (polymethacrylate) forms nanodiscs spontaneously by fragmentation or solubilization of the lipid bilayers. It is used in designing of nanodisc-forming polymer to mimic the amphiphilic nature of proteins and peptides. PMA N−C4−60−4.7 efficiently solubilised the lipid membrane and forms lipid nanodiscs with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). The addition of PMA N−C4−60−4.7 lowered the light scattering intensity of Escherichia coli suspension.

Packaging

5mL glass amber screw cap vial (880134P-100mg)
20mL clear glass screw cap vial (880134P-500mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Spontaneous lipid nanodisc fomation by amphiphilic polymethacrylate copolymers
Yasuhara K, et al.
Journal of the American Chemical Society, 139(51), 18657-18663 (2017)
Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8

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