890890C

18:1 TAP (DOTAP)

Avanti Polar Lipids

• Synonym(s): 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)
• Empirical Formula (Hill Notation): C₄₂H₈₀NO₄Cl
• CAS Number: 132172-61-3
• Molecular Weight: 698.54
• NACRES: NA.25

Properties

• form: liquid
• packaging: pkg of 1 × 2.5 mL (890890C-25mg); pkg of 2 × 20 mL (890890C-1g); pkg of 2 × 4 mL (890890C-200mg); pkg of 5 × 4 mL (890890C-500mg)
• manufacturer/tradename: Avanti Polar Lipids
• concentration: 10 mg/mL (890890C-25mg); 25 mg/mL (890890C-1g); 25 mg/mL (890890C-200mg); 25 mg/mL (890890C-500mg)
• application(s): advanced drug delivery
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]
• InChI: 1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;
• InChI key: KSXTUUUQYQYKCR-LQDDAWAPSA-M

Description

Application

18:1 TAP (DOTAP) has been used in the preparation of liposome-supported bilayers.

Biochem/physiol Actions

18:1 TAP (DOTAP) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP(1,2-dioleoyl-3-trimethylammonium-propane). 18:1 TAP (DOTAP) mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (890890C-1g)

5 mL Clear Glass Sealed Ampule (890890C-200mg)

5 mL Clear Glass Sealed Ampule (890890C-25mg)

5 mL Clear Glass Sealed Ampule (890890C-500mg)

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 - H412
• Precautionary Statements: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable