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900128E

Avanti

15(S)-HETE

Avanti Polar Lipids, ethanol solution

Synonym(s):
15S-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
Empirical Formula (Hill Notation):
C20H32O3
CAS Number:
Molecular Weight:
320.47
NACRES:
NA.25

assay

>99% (TLC)

form

ethanol solution

packaging

pkg of 1 × 1 mL (900128E-100UG)
pkg of 1 × 1 mL (900128E-500UG)

manufacturer/tradename

Avanti Polar Lipids

concentration

100 μg/mL in ethanol (900128E-100UG)
500 μg/mL in ethanol (900128E-500UG)

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1

InChI key

JSFATNQSLKRBCI-VAEKSGALSA-N

General description

15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).

Biochem/physiol Actions

15(S)-HETE plays a role in various biological actions. It may play a role in pathogenesis and prevention of airway inflammatory disorders. 15(S)-HETE is involved in inhibiting cell proliferation and induces apoptosis in various human cancers.

Packaging

2 mL Amber Glass Sealed Ampule (900128E-100UG and 900128E-500UG)

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

55.4 °F

Flash Point(C)

13 °C

Certificate of Analysis

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Certificate of Origin

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15 (S)-HETE modulates LTB4 production and neutrophil chemotaxis in chronic bronchitis
Profita M, et al.
American Journal of Physiology. Cell Physiology, 279(4), C1249-C1258 (2000)
Huiling Yuan et al.
Thorax, 65(4), 321-326 (2010-04-15)
15-S-Hydroxyeicosatetraenoic acid (15(S)-HETE) and 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), both of which are metabolites of 15-lipoxygenases (15-LOXs), are endogenous ligands for peroxisome proliferator-activated receptor gamma (PPARgamma). The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of

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