900128E

15(S)-HETE

Avanti Polar Lipids, ethanol solution

• Synonym(s): 15S-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
• Empirical Formula (Hill Notation): C₂₀H₃₂O₃
• CAS Number: 54845-95-3
• Molecular Weight: 320.47
• NACRES: NA.25

Properties

• assay: >99% (TLC)
• form: ethanol solution
• packaging: pkg of 1 × 1 mL (900128E-100UG); pkg of 1 × 1 mL (900128E-500UG)
• manufacturer/tradename: Avanti Polar Lipids
• concentration: 100 μg/mL in ethanol (900128E-100UG); 500 μg/mL in ethanol (900128E-500UG)
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
• InChI key: JSFATNQSLKRBCI-VAEKSGALSA-N

Description

General description

15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).

Biochem/physiol Actions

15(S)-HETE plays a role in various biological actions. It may play a role in pathogenesis and prevention of airway inflammatory disorders. 15(S)-HETE is involved in inhibiting cell proliferation and induces apoptosis in various human cancers.

Packaging

2 mL Amber Glass Sealed Ampule (900128E-100UG and 900128E-500UG)

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225 - H319
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 55.4 °F
• Flash Point(C): 13 °C