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999993P

Avanti

14:0 Diether PC

1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine, powder

Empirical Formula (Hill Notation):
C36H76NO6P
CAS Number:
Molecular Weight:
649.97
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (999993P-10mg)
pkg of 1 × 25 mg (999993P-25mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCCCCCCCCCC)COCCCCCCCCCCCCCC)=O

General description

14:0 Diether PC (phosphocholine) is a glycerophospholipid having choline as the alcohol moiety, attached to the phosphate group. It has two tetradecyl chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds.

Application

14:0 Diether PC or 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine might be used:
  • to prepare bicelle samples for solid-state NMR experiment
  • to compose isotropically tumbling small bicelles, to study its size and morphology
  • in lipid bicelles to reconstitute EmrE (secondary active transport protein)

Packaging

5 mL Amber Glass Screw Cap Vial (999993P-25mg)
5 mL Amber Glass Screw Cap Vial (999993P-10mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Certificate of Analysis

Certificate of Origin

Assessing interactions between a polytopic membrane protein and lipid bilayers using differential scanning calorimetry and solid-state NMR
Banigan JR, et al.
The Journal of Physical Chemistry B, 122(8), 2314-2322 (2018)
Assessing the size, stability, and utility of isotropically tumbling bicelle systems for structural biology
Wu H, et al.
Biochimica et Biophysica Acta - Biomembranes, 1798(3), 482-488 (2010)
Expression and purification of the membrane protein p7 from hepatitis C virus
Cook GA, et al.
Pept. Sci., 96(1), 32-40 (2011)
H A Pérez et al.
Langmuir : the ACS journal of surfaces and colloids, 36(10), 2644-2653 (2020-02-20)
The lack of carbonyl groups and the presence of ether bonds give the lipid interphase a different water organization around the phosphate groups that affects the compressibility and electrical properties of lipid membranes. Generalized polarization of 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (14:0 diether PC)...
Structural and functional roles of ether lipids
Dean JM and Lodhi IJ
Protein & cell, 9(2), 196-206 (2018)

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