LM2144

Sphingosine-1-Phosphate (d17:1)

Avanti Polar Lipids LM2144, ethanol solution

• Synonym(s): heptadeca-sphing-4-enine-1-phosphate
• Empirical Formula (Hill Notation): C₁₇H₃₆NO₅P
• CAS Number: 474923-27-8
• Molecular Weight: 365.45
• NACRES: NA.25

Properties

• form: ethanol solution
• packaging: pkg of 1 × 1 mL (LM2144-1EA)
• manufacturer/tradename: Avanti Polar Lipids LM2144
• concentration: ~10 μg/mL (Refer to C of A for lot specific concentration.)
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@]([NH3+])([H])COP([O-])(O)=O

Description

General description

Sphingosine-1-phosphate (S1P) is a sphingolipid found in yeast, plants and mammals and is produced in endothelial cells. It is a cellular metabolite and signalling lipid in mammalian cells. S1P is synthesized by sphingosine kinases from sphingosine. It is a high affinity ligand for sphingosine-1-phosphate receptor (S1P1-5).

Biochem/physiol Actions

Sphingosine 1-phosphate (S1P) plays a vital role as a secondary messenger in physiological processes. It is implicated in the pathogenesis of osteoporosis, cancer, atherosclerosis and diabetes. S1P regulates skin dendritic cells and keratinocytes

Packaging

2 mL Amber Glass Sealed Ampule (LM2144-1EA)

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225 - H319
• Precautionary Statements: P210 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 55.4 °F - closed cup
• Flash Point(C): 13.0 °C - closed cup