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LM2144

Avanti

Sphingosine-1-Phosphate (d17:1)

Avanti Polar Lipids LM2144, ethanol solution

Synonym(s):
heptadeca-sphing-4-enine-1-phosphate
Empirical Formula (Hill Notation):
C17H36NO5P
CAS Number:
Molecular Weight:
365.45
NACRES:
NA.25

form

ethanol solution

packaging

pkg of 1 × 1 mL (LM2144-1EA)

manufacturer/tradename

Avanti Polar Lipids LM2144

concentration

~10 μg/mL (Refer to C of A for lot specific concentration.)

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@]([NH3+])([H])COP([O-])(O)=O

General description

Sphingosine-1-phosphate (S1P) is a sphingolipid found in yeast, plants and mammals and is produced in endothelial cells. It is a cellular metabolite and signalling lipid in mammalian cells. S1P is synthesized by sphingosine kinases from sphingosine. It is a high affinity ligand for sphingosine-1-phosphate receptor (S1P1-5).

Biochem/physiol Actions

Sphingosine 1-phosphate (S1P) plays a vital role as a secondary messenger in physiological processes. It is implicated in the pathogenesis of osteoporosis, cancer, atherosclerosis and diabetes. S1P regulates skin dendritic cells and keratinocytes

Packaging

2 mL Amber Glass Sealed Ampule (LM2144-1EA)

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

55.4 °F - closed cup

Flash Point(C)

13.0 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More documents

Quotes and Ordering

High-Throughput Assays to Measure Intracellular Ca2+ Mobilization in Cells that Express Recombinant S1P Receptor Subtypes
Valentine WJ and Tigyi G
Methods in Molecular Biology, 77-87 (2012)
Sphingosine-1-phosphate as signaling molecule in the skin
Japtok L, et al.
Allergo journal international, 23(2), 54-59 (2014)
Sphingosine-1-phosphate: an enigmatic signalling lipid
Spiegel S and Milstien S
Nature Reviews in Molecular and Cell Biology, 4(5), 397-397 (2003)
Sphingosine-1-phosphate signaling and its role in disease
Maceyka M, et al.
Trends in Cell Biology, 22(1), 50-60 (2012)

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