LM6004

Avanti

d5-DG ISTD Mix II

d5-Diglyceride Mixture Internal Standard, toluene:methanol (1:1)

NACRES:
NA.25

packaging

pkg of 1 × 1 mL (LM6004-1EA)

manufacturer/tradename

Avanti Polar Lipids LM6004

concentration

~10 μg/mL (Refer to C of A for lot specific concentration. )

shipped in

dry ice

storage temp.

−20°C

General description

Deuterated diglyceride (DG) Mixture II contains: 1,3-16:1 D5 DG 1,3-18:0 D5 DG 1,3-18:1 D5 DG 1,3-18:2 D5 DG.

Application

d5-DG ISTD Mix II or d5-Diglyceride Mixture Internal Standard has been used as an internal standard mixture for diacylglycerol analysis by high-performance liquid chromatography/tandem mass spectrometry (LC/MS2). It has also been used as an internal standard mixture in lipid extraction from 3-hydroxy-isobutyrate (3-HIB)-fed mouse muscle samples and in liquid chromatography-mass spectrometry (LC-MS) lipidomics.

Packaging

2 mL Amber Glass Sealed Ampule (LM6004-1EA)

Signal Word

Danger

hazcat

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 1 - STOT SE 3

Target Organs

Central nervous system, Eyes

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 2

Certificate of Analysis

Certificate of Origin

Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity
Rivas DA, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 310(7), R561-R569 (2016)
Cholsoon Jang et al.
Nature medicine, 22(4), 421-426 (2016-03-08)
Epidemiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms that underlie this link remain unclear. Insulin resistance in skeletal muscle stems from the excess accumulation of lipid species, a process that...
R C Fitzgerald et al.
The Journal of clinical investigation, 98(9), 2120-2128 (1996-11-01)
Barrett's esophagus (BE), or specialized intestinal metaplasia, is a premalignant heterogeneous epithelium associated with reflux and an increased risk for adenocarcinoma. Since acid is a major component of refluxate, we investigated its effects ex vivo on cell differentiation as determined...
Donato A Rivas et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 310(7), R561-R569 (2016-01-15)
The loss of skeletal muscle mass is observed in many pathophysiological conditions, including aging and obesity. The loss of muscle mass and function with aging is defined as sarcopenia and is characterized by a mismatch between skeletal muscle protein synthesis...

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