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A-094

Supelco

Ascomycin solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C43H69NO12
CAS Number:
Molecular Weight:
792.01
EC Number:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−70°C

SMILES string

CCC1\C=C(C)\CC(C)CC(OC)C2OC(O)(C(C)CC2OC)C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)C(O)CC1=O)\C(C)=C\C4CCC(O)C(C4)OC

InChI

1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+

InChI key

ZDQSOHOQTUFQEM-AMASXYNMSA-N

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This Item
C-093M-136C-108
vibrant-m

A-094

Ascomycin solution

vibrant-m

C-093

Cyclosporin A solution

vibrant-m

M-136

Methotrexate solution

vibrant-m

C-108

Cyclosporin D solution

form

liquid

form

liquid

form

liquid

form

liquid

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

General description

An internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants. The Snap-N-Spike® format provides laboratories the ability to spike into their matrix of choice just before use and allows them to eliminate weighing operations of hazardous substances which significantly reduces occupational exposure hazards related to handling acutely toxic powders such as immunosuppressants.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup


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Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard

Y0001926

Tacrolimus monohydrate

Tacrolimus United States Pharmacopeia (USP) Reference Standard

USP

1642802

Tacrolimus

Tacrolimus Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1809

Tacrolimus

Chemistry of the immunomodulatory macrolide ascomycin and related analogues.
Murty A R C Bulusu et al.
Progress in the chemistry of organic natural products, 94, 59-126 (2011-08-13)
Germán Sierra-Paredes et al.
CNS neuroscience & therapeutics, 14(1), 36-46 (2008-05-17)
Ascomycin and FK506 are powerful calcium-dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase 2B) inhibitors. Their mechanism of action involves the formation of a molecular complex with the intracellular FK506-binding protein-12 (FKBP12), thereby acquiring the ability to interact with CaN
John R Carney et al.
The Journal of antibiotics, 58(11), 715-721 (2006-02-10)
Three new ascomycins produced by genetic engineering of Streptomyces hygroscopicus ATCC 14891 have been purified and characterized. Replacement of the 13-methoxyl group of ascomycin was accomplished by substitution of the corresponding acyltransferase domain of the polyketide synthase with a domain
Patrizia Ferraboschi et al.
The Journal of antibiotics, 65(7), 349-354 (2012-04-19)
Tacrolimus is an immunosuppressant macrolactam of fermentative origin. By means of HPLC, LC-MS and NMR analyses, coupled with the reference standard synthesis, the main impurities of tacrolimus bulk drug samples were identified and their chemical-physical properties reported. Known ascomycin and
Heike Burhenne et al.
Biomedical chromatography : BMC, 26(6), 681-683 (2011-10-25)
The objective of this study was to develop a fast and robust method for the quantitation of the antifungal drug anidulafungin in human plasma samples by generic two-dimensional liquid chromatography (online-SPE/reversed phase LC) coupled to a tandem-quadrupole mass spectrometer (LC-online

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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