A-915

7-Aminoclonazepam solution

Name: 7-Aminoclonazepam solution
Brand: CERILLIAN
Price: 28.4 USD

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

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1 ML

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₂ClN₃O

CAS Number:

4959-17-5

Molecular Weight:

285.73

NACRES:

NA.24

PubChem Substance ID:

329771038

UNSPSC Code:

41116107

EC Number:

200-835-2

MDL number:

MFCD00798467

Key Documents

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InChI key

HEFRPWRJTGLSSV-UHFFFAOYSA-N

InChI

1S/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)

SMILES string

NC1=CC=C2C(C(C3=C(Cl)C=CC=C3)=NCC(N2)=O)=C1

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE^®, SNAP-N-SHOOT^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

300

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Controlled Substances & Illicit Drug Standards

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Show Differences

1 of 4

This Item	A-916	D-111	A-917
Supelco A-915 7-Aminoclonazepam solution	Supelco A-916 7-Aminoclonazepam solution	Supelco D-111 N-Desmethylzopiclone solution	Supelco A-917 7-Aminoclonazepam-d₄ solution
application(s) clinical testing	application(s) clinical testing	application(s) clinical testing	application(s) clinical testing
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable
form liquid	form liquid	form liquid	form liquid
format single component solution	format single component solution	format single component solution	format single component solution
Quality Level 300	Quality Level 300	Quality Level 300	Quality Level 300
grade certified reference material	grade certified reference material	grade certified reference material	grade certified reference material

General description

This certified Snap-N-Spike^® solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing. As a major metabolite, 7-aminoclonazepam may be used to monitor use of the parent drug, clonazepam. Clonazepam, marketed as Klonopin^® and Rivotril, is a long-acting benzodiazepine with anxiolytic, anticonvulsant, muscle relaxant, and hypnotic properties.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Klonopin is a registered trademark of Hoffmann-La Roche Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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7-Aminoclonazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

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D-159

Diclazepam solution, 1 mg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant^®

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Meclonazepam solution, 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant^®

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Meclonazepam-D₃ solution, 100 μg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant^®

D-160

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pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H302 + H312 + H332,H319

pcodes

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimes.

Marjorie Chèze et al.

Forensic science international, 145(2-3), 123-130 (2004-09-29)

The number of reports on drug facilitated crimes is increasing these last years. Apart from ethanol and cannabis, benzodiazepines (BZD) and analogs are the most common drugs reported to be used probably due to their amnesic and sedative properties. We

Elimination of 7-aminoclonazepam in urine after a single dose of clonazepam.

Adam Negrusz et al.

Analytical and bioanalytical chemistry, 376(8), 1198-1204 (2003-07-08)

The objective of this paper was to determine how long after administration of benzodiazepine clonazepam (CLO), its major metabolite 7-aminoclonazepam (7-ACLO) could be detected in urine collected from 10 healthy volunteers who received a single 3-mg dose of Klonopin (clonazepam).

Deposition of 7-aminoclonazepam and clonazepam in hair following a single dose of Klonopin.

Adam Negrusz et al.

Journal of analytical toxicology, 26(7), 471-478 (2002-11-09)

The objective of this paper was to determine whether benzodiazepine clonazepam (CLO) and its major metabolite 7-aminoclonazepam (7-ACLO) could be detected in hair collected from healthy volunteers after receiving a single 3-mg dose of Klonopin (clonazepam). Such data would be

Quantitation of clonazepam and its 7-amino and 7-acetamido metabolites in plasma by high-performance liquid chromatography.

I Petters et al.

Journal of chromatography, 306, 241-248 (1984-03-09)

A high-performance liquid chromatographic method is reported for the determination of clonazepam and its metabolites 7-amino- and 7-acetamidoclonazepam. Extraction from buffered plasma is carried out at pH 9.5 with hexane-ethyl acetate (7:3) for clonazepam and with chloroform for the metabolites.

Polymorphic acetylation of 7-amino-clonazepam in human liver cytosol.

D R Peng et al.

Pediatric pharmacology (New York, N.Y.), 4(3), 155-159 (1984-01-01)

The N-acetylation of the reduced metabolite of clonazepam 7-amino-clonazepam was studied in cytosolic preparation from human fetal and adult livers. The metabolite formed 7-acetamido-clonazepam was measured with high performance liquid chromatography. A bimodal distribution of the N-acetyltransferase activities was observed

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