C-060

Cyclobenzaprine hydrochloride solution

Name: Cyclobenzaprine hydrochloride solution
Brand: CERILLIAN
Price: 40.8 USD

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

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1 ML

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₂ClN

CAS Number:

6202-23-9

Molecular Weight:

311.85

UNSPSC Code:

41116107

MDL number:

MFCD00079039

NACRES:

NA.24

EC Number:

200-659-6

Key Documents

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Product Name

Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

InChI key

VXEAYBOGHINOKW-UHFFFAOYSA-N

InChI

1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H

SMILES string

Cl.CN(C)CC\C=C1\c2ccccc2C=Cc3ccccc13

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE^®, SNAP-N-SHOOT^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

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Show Differences

1 of 4

This Item	C-114	M-074	M-202
Supelco C-060 Cyclobenzaprine hydrochloride solution	Supelco C-114 Cyclobenzaprine-D₃ hydrochloride solution	Supelco M-074 Metaxalone solution	Supelco M-202 Methocarbamol-D₃ solution
application(s) clinical testing	application(s) clinical testing	application(s) clinical testing	application(s) clinical testing
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable
form liquid	form liquid	form liquid	form liquid
format single component solution	format single component solution	format single component solution	format single component solution
Quality Level 300	Quality Level 300	Quality Level 300	Quality Level 300
grade certified reference material	grade certified reference material	grade certified reference material	grade certified reference material

General description

Cyclobenzaprine is a muscle relaxant sold under the trade name Flexeril^® to relieve skeletal muscle spasms and associated pain from acute musculoskeletal conditions. This Snap-N-Spike^® Reference Solution is suitable for use in LC/MS or GC/MS methods for clinical toxicology, forensic analysis, or urine drug testing applications.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Flexeril is a registered trademark of ALZA Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.

Description

Pricing

C-114

Cyclobenzaprine-D₃ hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H370

pcodes

P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose.

Vikhyat S Bebarta et al.

The American journal of emergency medicine, 30(2), 374-374 (2011-11-22)

Erythema multiforme vs. DRESS syndrome associated with the combined use of lamotrigine and cyclobenzaprine: a case report.

Lindsay T Morgan Bicknell et al.

International journal of psychiatry in medicine, 44(4), 305-314 (2012-01-01)

Lamotrigine is FDA-approved as a maintenance treatment of bipolar disorder, but its common off-label uses include bipolar depression and antidepressant augmentation in patients with major depressive disorder. Among other adverse effects, cutaneous reactions, particularly erythema multiforme, are cited as concerns

Is there sufficient evidence to suggest cyclobenzaprine might be implicated in causing serotonin toxicity?

P Ken Gillman

The American journal of emergency medicine, 27(4), 509-510 (2009-06-27)

Chlorpromazine quantification in human plasma by UPLC-electrospray ionization tandem mass spectrometry. Application to a comparative pharmacokinetic study.

Ney Carter Borges et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(31), 3728-3734 (2011-11-15)

In the present study a method to quantify chlorpromazine in human plasma using cyclobenzaprine as the internal standard (IS) is described. The analyte and the IS were extracted from human plasma by a liquid-liquid extraction with diethyl ether/dichloromethane (70/30, v/v)

Determination of cyclobenzaprine in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study.

Yi Xiang et al.

Biomedical chromatography : BMC, 26(9), 1083-1088 (2011-11-29)

A sensitive, rapid and simple liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS/MS) method was developed for the quantitative determination of cyclobenzaprine in human plasma, to study the pharmacokinetic behavior of cyclobenzaprine capsule in healthy Chinese volunteers. With escitalopram as the internal

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