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C-116

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Clomipramine-d3 hydrochloride solution

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Clomipramine-D3 hydrochloride solution

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About This Item

Empirical Formula (Hill Notation):
C19D3H20ClN2 · HCl
CAS Number:
Molecular Weight:
354.33
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H/i1D3;

InChI key

WIMWMKZEIBHDTH-NIIDSAIPSA-N

General description

Clomipramine is a tricyclic antidepressant used to many conditions from major depression and panic disorder to narcolepsy and obsessive compulsion disorder (OCD). This internal standard is is suitable for quantitation of Clomipramine levels in urine, serum, or plasma by LC/MS or GC/MS for applications in clinical toxicology, forensic analysis, isotope dilution methods, or pharmaceutical research.

Application

  • Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression.: This study investigates the metabolic profiles in the brain following different administration routes of clomipramine in a rat model of depression, providing insights into its pharmacokinetics and pharmacodynamics (Abramova et al., 2021).
  • Serotonergic regulation of the buccal (feeding) rhythm of the pond snail, Lymnaea stagnalis. An immunocytochemical, biochemical and pharmacological approach.: This research explores the serotonergic regulation in pond snails, employing clomipramine to understand its role in modulating neural rhythms, which has implications for understanding neurotransmitter systems (Elekes et al., 2018).
  • Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression.: This study uses proteomic techniques to investigate changes in the prefrontal cortex of rats treated with clomipramine, contributing to the understanding of its impact on brain protein expression in depressive states (Gellén et al., 2017).
  • A qualitative method for prediction of amine oxidation in methanol and water.: The paper presents a method for predicting amine oxidation, utilizing clomipramine as a case study, highlighting its importance in understanding chemical stability in various solvents (Bäcktorp et al., 2015).
  • Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.: This research identifies potential biomarkers for drug-induced hepatic phospholipidosis, with clomipramine used to validate the biomarkers, aiding in the development of safer pharmaceuticals (Saito et al., 2014).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Luiza G Tunes et al.
ACS infectious diseases, 6(5), 1121-1139 (2020-04-15)
The drugs currently used to treat leishmaniases have limitations concerning cost, efficacy, and safety, making the search for new therapeutic approaches urgent. We found that the gold(I)-derived complexes were active against L. infantum and L. braziliensis intracellular amastigotes with IC50 values ranging

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