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C-117

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Corticosterone solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
Molecular Weight:
346.46
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C1CCC2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

General description

Corticosterone is a corticosteroid and aldosterone precursor produced in the adrenal glands. Serum corticosterone levels are measured by LC-MS/MS for newborn screening and diagnosis of 11-hydroxylase deficiency.

Application


  • Corticosterone ELISA kit for stress hormone research: Research has demonstrated the efficacy of corticosterone ELISA kits in measuring stress hormone levels, contributing significantly to studies on adrenal gland function and stress-related disorders. This application is vital for in vivo corticosterone analysis, allowing detailed monitoring of hormone fluctuations in response to various stressors (Ornelas et al., 2024).

  • High-purity corticosterone for receptor binding assays: Corticosterone solutions are extensively used in receptor binding assays to understand corticosteroid receptor interactions. These studies are crucial for advancing knowledge in endocrinology biochemical studies, particularly in mapping corticosteroid pathways and their effects within the body (Xie et al., 2024).

  • Synthetic corticosterone solution for endocrine studies: Synthetic corticosterone is employed in clinical experimental setups to examine the endocrine system′s response under controlled conditions. This usage is particularly evident in studies focusing on the adaptation of the endocrine system to external stress factors and its impact on overall physiological health (Costa et al., 2024).

  • Liquid corticosterone for stress response research: Liquid formulations of corticosterone are pivotal in conducting stress response research, providing a consistent and measurable means of administering this hormone to study its acute and chronic effects on animal behavior and physiological responses (Ornelas et al., 2023).

  • Corticosterone reagent for glucocorticoid receptor experiments: As a reagent, corticosterone is integral to glucocorticoid receptor experiments, which are essential for understanding glucocorticoid receptor dynamics and their implications in various physiological processes, including immune response and metabolic regulation (Heraudeau et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificates of Analysis (COA)

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Soraya L Valles et al.
Journal of translational medicine, 11, 72-72 (2013-03-23)
Interleukin (IL)-6 (mainly of tumor origin) activates glutathione (GSH) release from hepatocytes and its interorgan transport to B16-F10 melanoma metastatic foci. We studied if this capacity to overproduce IL-6 is regulated by cancer cell-independent mechanisms. Murine B16-F10 melanoma cells were
T V Shemenkova et al.
Bulletin of experimental biology and medicine, 154(4), 464-466 (2013-03-15)
ACTH1-24(1 mg/kg) administered to 5-7-day-old rats reduced their locomotor activity and did not alter blood levels of corticosterone. ACTH administration on postnatal days 12-14 increased corticosterone levels, but had no effect on locomotor activity. Thus, the behavioral effect of ACTH
Atish Mukherji et al.
Cell, 153(4), 812-827 (2013-05-15)
Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic
Kathan Chintamaneni et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R782-R789 (2013-03-15)
Apnea, the temporary cessation of respiratory airflow, is a common cause of intermittent hypoxia (IH) in premature infants. We hypothesized that IH elicits a stress response and alters glucose homeostasis in the neonatal rat. Rat pups were studied on postnatal
Krzysztof Gil et al.
Neuro endocrinology letters, 34(4), 314-321 (2013-06-28)
The brain and the gut communicate bi-directionally through the brain-gut axis. The key role in such interactions plays autonomic nervous system and its major component, the vagus nerve. There is growing evidence that vagus nerve stimulation (VNS) has a suppressive

Protocols

The conversion of clinical methods to LC/MS/MS offers advantages; however, is accompanied by a few limitations, notably interference effects from the endogenous sample matrix.

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