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N-Desmethylclobazam solution

Name: N-Desmethylclobazam solution
Brand: CERILLIAN
Price: 278 USD

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

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Pack Size	SKU	Availability	Price
1 mL		Check Cart for Availability	$278.00

About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₁ClN₂O₂

CAS Number:

22316-55-8

Molecular Weight:

286.71

NACRES:

NA.24

PubChem Substance ID:

329798612

UNSPSC Code:

41116107

EC Number:

200-835-2

MDL number:

MFCD00871860

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Properties

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

O=C(C1)N(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O

InChI

1S/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19)

InChI key

RRTVVRIFVKKTJK-UHFFFAOYSA-N

Description

General description

A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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This Item	D-094	D-111	D-128
Supelco D-049 N-Desmethylclobazam solution	Supelco D-094 N-Desmethylclobazam-8-chloro isomer-¹³C₆ solution	Supelco D-111 N-Desmethylzopiclone solution	Supelco D-128 N-Desmethylclobazam-¹³C₆ solution
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable
form liquid	form liquid	form liquid	form liquid
format single component solution	format single component solution	format single component solution	format single component solution
Quality Level 300	Quality Level 300	Quality Level 300	Quality Level 300
grade certified reference material	grade certified reference material	grade certified reference material	grade certified reference material
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

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pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H302 + H312 + H332,H319

pcodes

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Certificates of Analysis (COA)

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Clobazam and norclobazam quantitation in serum by capillary gas chromatography with electron-capture detection.

D F LeGatt et al.

Clinical biochemistry, 26(3), 159-163 (1993-06-01)

We have developed a simple, rapid method for determination of the antiepileptic drug clobazam and its major active metabolite, norclobazam in serum. Serum (200 microL) made alkaline with sodium borate buffer is extracted with toluene. After evaporation of the organic

Automated on-line dialysis for sample preparation for gas chromatography: determination of benzodiazepines in human plasma.

R Herráez-Hernández et al.

Journal of pharmaceutical and biomedical analysis, 14(8-10), 1077-1087 (1996-06-01)

An on-line dialysis-solid-phase extraction-gas chromatographic (GC) approach has been developed for the determination of drugs in plasma, using some benzodiazepines as model compounds. Clean-up is based on performing the dialysis of 100 microliters samples for 7 min using water as

Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB.

Masako Kinoshita et al.

Journal of the neurological sciences, 263(1-2), 44-48 (2007-06-26)

We evaluated the efficacy of low-dose, add-on therapy of CLB in adults with refractory epilepsy. 28 patients were included: 12 with temporal lobe epilepsy (TLE), 14 with extratemporal lobe epilepsy (ETLE) and 2 with symptomatic generalized epilepsy (SGE). CLB was

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Global Trade Item Number

SKU	GTIN
D-049-1ML	04061833553947

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