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N-Desmethyltrimipramine maleate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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Synonym(s):
N-Desmethyltrimipramine maleate solution
Empirical Formula (Hill Notation):
C19H24N2 · C4H4O4
CAS Number:
Molecular Weight:
396.48
EC Number:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

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This Item
T-071I-903D-906
form

liquid

form

liquid

form

liquid

form

liquid

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

concentration

100 μg/mL in methanol (as free base)

concentration

100 μg/mL in methanol (as free base)

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

General description

N-Desmethyltrimipramine is a primary blood metabolite of trimipramine. Trimipramine is a tricyclic antidepressant prescribed for treatment of depression, insomnia, and chronic pain or as an adjunctive therapy for alcohol or opioid withdrawal. This Certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications for pain prescription monitoring, urine drug testing, clinical toxicology, and forensic analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup


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D R Abernethy et al.
Clinical pharmacology and therapeutics, 35(3), 348-353 (1984-03-01)
Kinetic parameters were derived from trimipramine and desmethyltrimipramine plasma concentrations after administration of intravenous (12.5 mg) and oral (50 mg) trimipramine in nine subjects. Elimination t1/2 after intravenous dosing was (mean +/- SE) 23 +/- 1.9 hr. Volume of distribution
Dose-dependent kinetics of trimipramine.
M N Musa
The Journal of clinical psychiatry, 50(8), 307-307 (1989-08-01)
J Degen et al.
Medizinische Klinik (Munich, Germany : 1983), 88(3), 129-133 (1993-03-15)
The pharmacokinetics of the antidepressants amitriptyline oxide and trimipramine and their major metabolites amitriptyline, nor-triptyline and desmethyltrimipramine, were studied in twelve healthy male subjects (aged from 22 to 62 years) and twelve patients (aged from 25 to 73 years) with
J Liu et al.
Journal of chromatography. B, Biomedical sciences and applications, 700(1-2), 175-182 (1997-12-09)
A sensitive and stereospecific method for the quantitation of trimipramine enantiomers in human serum was developed. The assay involves the use of a novel mixed-mode disc solid-phase extraction for serum sample clean-up prior to HPLC analysis and is also free
In vitro metabolism of desmethyltrimipramine to yield hydroxylamino compound.
S Ozkirimli et al.
Acta pharmaceutica Suecica, 23(1), 57-59 (1986-01-01)

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