E-006

EDDP perchlorate

Name: EDDP perchlorate
Brand: CERILLIAN
Price: 93.2 USD

ampule of 10 mg, certified reference material, Cerilliant^®

Synonym(s):

EDDP perchlorate, 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate

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10 MG

$93.20

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₃N · HClO₄

CAS Number:

31161-17-8

Molecular Weight:

377.86

MDL number:

MFCD08064190

NACRES:

NA.24

PubChem Substance ID:

329798940

UNSPSC Code:

41116107

Key Documents

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grade

certified reference material

form

solid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 10 mg

manufacturer/tradename

Cerilliant^®

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

neat

storage temp.

−20°C

Quality Level

300

Related Categories

Certified Reference Materials

Controlled Substances & Illicit Drug Standards

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1 of 4

This Item	E-022	E-021	E-062
Supelco E-006 EDDP perchlorate	Supelco E-022 EDDP perchlorate solution	Supelco E-021 EDDP-D₃ perchlorate solution	Supelco E-062 EDDP-D₃ perchlorate solution
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable
format neat	format single component solution	format single component solution	format single component solution
form solid	form liquid	form liquid	form liquid
Quality Level 300	Quality Level 300	Quality Level 300	Quality Level 300
grade certified reference material	grade certified reference material	grade certified reference material	grade certified reference material
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

General description

A Certified Reference Material of the major urinary metabolite of methadone. Methadone, sold under various trade names such as Symoron, Amidone or Methadose^®, is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. Suitable uses for this reference standard include as starting material in preparation of calibrators and controls for LC/MS or GC/MS methods in methadone testing for applications in clinical toxicology or forensic analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Methadose is a registered trademark of Mallinckrodt Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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(±)-Methadone solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

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Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant^®

O-020

Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant^®

E-021

EDDP-D₃ perchlorate solution, 100 μg/mL in methanol (as pyrrolinium), ampule of 1 mL, certified reference material, Cerilliant^®

E-022

EDDP perchlorate solution, 1.0 mg/mL in methanol (as pyrolinium), ampule of 1 mL, certified reference material, Cerilliant^®

E-057

EMDP hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

E-062

EDDP-D₃ perchlorate solution, 1.0 mg/mL in methanol (as pyrrolinium), ampule of 1 mL, certified reference material, Cerilliant^®

M-008

(±)-Methadone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

M-019

(±)-Methadone solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

M-021

(±)-Methadone-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

M-088

(±)-Methadone-D₉ solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

M-089

(±)-Methadone-D₉ solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

pictograms

GHS06

signalword

Danger

hcodes

H301,H336

pcodes

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sweat testing to monitor drug exposure.

Cristiana Gambelunghe et al.

Annals of clinical and laboratory science, 43(1), 22-30 (2013-03-07)

It may be advantageous to use sweat, rather than blood or urine, to monitor individuals' drug exposure for the purposes of drug treatment programs, employment initiatives, and forensic investigations. Forty-eight patients receiving methadone at the Public Service for the Treatment

Chiral analysis of methadone and its main metabolite, EDDP, in postmortem brain and blood by automated SPE and liquid chromatography-mass spectrometry.

Karen Marie Dollerup Holm et al.

Journal of analytical toxicology, 36(7), 487-496 (2012-07-11)

We developed a method based on liquid chromatography coupled with tandem mass spectrometry to quantify individual enantiomers of methadone and its primary metabolite, R/S-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP), in postmortem blood and brain tissue. Samples were prepared with a Tecan Evo robotic system.

[Develop rapid and inexpensive method for the determination of methadone and its major metabolites for monitoring therapy].

Maksymilian Kulza et al.

Przeglad lekarski, 67(10), 925-928 (2010-01-01)

Methadone maintenance therapy is one of the most popular treatments for opiate addiction. The easiest and the most reliable way to monitor the accuracy of the therapy is determination of methadone and its metabolites in biological material. The aim of

Postmortem blood and tissue concentrations of R- and S-enantiomers of methadone and its metabolite EDDP.

Ricarda Jantos et al.

Forensic science international, 226(1-3), 254-260 (2013-02-21)

Body fluids and tissues in 16 methadone (MTD)-associated fatalities were investigated to find out whether analysis of MTD and its metabolite 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) following enantioselective separation of both compounds may assist in the interpretation of MTD findings. Individual case histories

Evaluating the relationship of methadone concentrations and EDDP formation in chronic pain patients.

Edijs Leimanis et al.

Journal of analytical toxicology, 36(4), 239-249 (2012-04-19)

Methadone is used to treat moderate to severe pain in patients not responsive to non-narcotic analgesics and for maintenance treatment of opioid addiction. Methadone is primarily metabolized by N-demethylation to an inactive metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidene (EDDP) by CYP3A4 and CYP2B6. Establishing

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