Documents
H-921
α-Hydroxymidazolam-d4 solution
100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
100 μg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
2-8°C
SMILES string
[2H]c1c([2H])c([2H])c(c(F)c1[2H])C2=NCc3cnc(CO)n3-c4ccc(Cl)cc24
InChI
1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2/i1D,2D,3D,4D
InChI key
QHSMEGADRFZVNE-RHQRLBAQSA-N
1 of 4
This Item | C-040 | T-909 | A-924 |
|---|---|---|---|
| form liquid | form liquid | form liquid | form liquid |
| packaging ampule of 1 mL | packaging ampule of 1 mL | packaging ampule of 1 mL | packaging ampule of 1 mL |
| manufacturer/tradename Cerilliant® | manufacturer/tradename Cerilliant® | manufacturer/tradename Cerilliant® | manufacturer/tradename Cerilliant® |
| concentration 100 μg/mL in methanol | concentration 100 μg/mL in methanol | concentration 100 μg/mL in methanol | concentration 1.0 mg/mL in acetonitrile |
| technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable |
General description
It is an internal standard of α-hydroxymidazolam, a major metabolite of the benzodiazepine midazolam, formed upon its metabolism by cytochrome P450 3A (CYP3A) isoenzymes.
Application
The Certified Reference Material (CRM) in solution can also be used as follows:
- Liquid chromatography-tandem mass spectrometry (LC–MS/MS) method based determination of 12 psychotropic drugs and their metabolites in guinea pig hair samples
- Multiresidue analysis of 18 benzodiazepines in human blood and hair samples using LC–MS/MS
- Detection and estimation of 21 benzodiazepines and three z-drugs from human hair samples after their two-step extraction by LC–MS/MS
- Simultaneous analysis of 54 benzodiazepine and three z-drug residues from human urine and blood samples by ultra high-performance liquid chromatography- triple quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS) method
- Analysis of 26 compounds, comprising 18 benzodiazepines, seven benzodiazepine metabolites, and one z-drug from dried blood spot (DBS) cards using LC-MS/MS
Features and Benefits
- Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
- Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
- Rigorously tested through real-time stability studies to ensure accuracy and shelf life
- Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
- Flame sealed under argon into ampoules for long-term shelf life
- Offered in a convenient, DEA-exempt format to improve laboratory efficiency
Legal Information
related product
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
49.5 °F - closed cup
Flash Point(C)
9.7 °C - closed cup
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