M-132

MSTFA Reagent

ampule of 10 × 1.2 mL, analytical standard, Cerilliant^®

• Synonym(s): N-Methyl-N-(trimethylsilyl)trifluoroacetamide, N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA
• Linear Formula: CF₃CON(CH₃)Si(CH₃)₃
• CAS Number: 24589-78-4
• Molecular Weight: 199.25
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329817869
• EC Number: 246-331-6
• Beilstein/REAXYS Number: 1941550
• MDL number: MFCD00000411

Properties

• grade: analytical standard
• vapor density: >1 (vs air)
• vapor pressure: 8.8 mmHg ( 27 °C)
• reaction suitability: reagent type: derivatization reagent; reaction type: Acylations
• packaging: ampule of 10 × 1.2 mL
• manufacturer/tradename: Cerilliant^®
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.38 (lit.)
• bp: 130-132 °C (lit.)
• density: 1.075 g/mL at 25 °C (lit.)
• application(s): forensics and toxicology
• format: neat
• storage temp.: −20°C
• SMILES string: CN(C(=O)C(F)(F)F)[Si](C)(C)C
• InChI: 1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3
• InChI key: MSPCIZMDDUQPGJ-UHFFFAOYSA-N

Description

General description

MSTFA (N-Methyl-N-trimethylsilylfluoroacetamide) is an important trimethylsilyl reagent, and a commonly applied reagent since it is highly reactive towards a broad range of compound classes. GC-MS optimization studies reveal the use of this reagent either alone or in combination with 1% of trimethylchlorosilane as a catalyst for silylation of complex mixtures. It has similar reactivity as BSA and BSTFA.

Application

MSTFA reagent may be used as a derivatizing agent in the following:

• Analysis of estrogen steroids such as estrone (E1), 17α-ethinylestradiol (EE2)[1], and trenbolone acetate metabolites, melengestrol in environmental matrices using gas chromatography coupled to mass spectrometry (GC-MS).
• Quantification of ibuprofen, naproxen, ketoprofen, and diclofenac in wastewater samples using gas chromatography coupled to mass spectrometry (GC-MS).

Features and Benefits

• Very volatile of TMS-acetamides.
• More volatile than BSA or BSTFA but with similar silylation strength.
• Useful in the analysis of volatile trace materials.
• Used in the preparation of volatile and thermally stable derivatives for GC and MS analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS07
• signalword: Warning
• hcodes: H226,H315,H319,H335
• pcodes: P210 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 3 - Flammable liquids
• wgk: WGK 3
• flash_point_f: 77.0 °F - closed cup
• flash_point_c: 25 °C - closed cup