N-059

Norbuprenorphine solution

Name: Norbuprenorphine solution
Brand: CERILLIAN
Price: 448 USD
Availability: InStock

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₃₅NO₄

CAS Number:

78715-23-8

Molecular Weight:

413.55

NACRES:

NA.24

UNSPSC Code:

41116107

Key Documents

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Product Name

Norbuprenorphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

application(s)

forensics and toxicology

InChI

1S/C25H35NO4/c1-21(2,3)22(4,28)16-13-23-8-9-25(16,29-5)20-24(23)10-11-26-17(23)12-14-6-7-15(27)19(30-20)18(14)24/h6-7,16-17,20,26-28H,8-13H2,1-5H3/t16-,17-,20-,22+,23-,24+,25-/m1/s1

InChI key

YOYLLRBMGQRFTN-IOMBULRVSA-N

SMILES string

CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O)c6O[C@@H]2[C@]3(CCN4)c56

grade

certified reference material

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

format

single component solution

shipped in

wet ice

storage temp.

−20°C

Quality Level

300

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Show Differences

1 of 4

This Item	N-912	B-044	N-012
Supelco N-059 Norbuprenorphine solution	Supelco N-912 Norbuprenorphine solution	Supelco B-044 Buprenorphine solution	Supelco N-012 Noroxymorphone hydrochloride solution
application(s) forensics and toxicology	application(s) forensics and toxicology	application(s) forensics and toxicology	application(s) forensics and toxicology
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable
form liquid	form liquid	form liquid	form liquid
format single component solution	format single component solution	format single component solution	format single component solution
Quality Level 300	Quality Level 300	Quality Level 300	Quality Level 300
grade certified reference material	grade certified reference material	grade certified reference material	grade certified reference material

General description

A new Certified Spiking Solution^® suitable for use in clinical toxicology, forensic testing, or pain prescription monitoring.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H370

pcodes

P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice.

Hisham Alhaddad et al.

Critical care medicine, 40(12), 3215-3223 (2012-09-15)

Deaths due to asphyxia as well as following acute poisoning with severe respiratory depression have been attributed to buprenorphine in opioid abusers. However, in human and animal studies, buprenorphine exhibited ceiling respiratory effects, whereas its metabolite, norbuprenorphine, was assessed as

Intravenous and sublingual buprenorphine in horses: pharmacokinetics and influence of sampling site.

Kristen M Messenger et al.

Veterinary anaesthesia and analgesia, 38(4), 374-384 (2011-04-20)

To describe the pharmacokinetics and adverse effects of intravenous (IV) and sublingual (SL) buprenorphine in horses, and to determine the effect of sampling site on plasma concentrations after SL administration. Randomized crossover experiment; prospective study. Eleven healthy adult horses between

Patterns of free (unconjugated) buprenorphine, norbuprenorphine, and their glucuronides in urine using liquid chromatography-tandem mass spectrometry.

Gwendolyn A McMillin et al.

Journal of analytical toxicology, 36(2), 81-87 (2012-02-18)

Patterns of buprenorphine and metabolites were examined in 1946 positive urine samples analyzed by liquid chromatography-tandem mass spectrometry for free (unconjugated) buprenorphine and norbuprenorphine (quantitative, 2 to 1000 ng/mL) and buprenorphine-glucuronide (B3G) and norbuprenorphine-glucuronide (N3G) (semi-quantitative, 5 to 1000 ng/mL).

Estimated dose exposure of the neonate to buprenorphine and its metabolite norbuprenorphine via breastmilk during maternal buprenorphine substitution treatment.

Kenneth F Ilett et al.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 7, 269-274 (2011-10-21)

The aim of the present study was to estimate the dose of buprenorphine and its primary metabolite norbuprenorphine that a breastfed infant would receive during maternal maintenance treatment with buprenorphine. Seven pregnant opioid-dependent women taking buprenorphine (median, 7 mg/day; range, 2.4-24 mg)

Toxicological and pathological findings in a series of buprenorphine related deaths. Possible risk factors for fatal outcome.

Tor Seldén et al.

Forensic science international, 220(1-3), 284-290 (2012-05-09)

Buprenorphine is considered to have little respiratory side effects at therapeutic doses and the partial agonistic properties should produce a "ceiling effect" for respiratory depression at higher doses. Still, there are several reports on buprenorphine related deaths. Most deaths involve

View All Related Papers

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-THC solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

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