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N-073

Supelco

Nimetazepam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C16H13N3O3
CAS Number:
Molecular Weight:
295.29
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CN1C(=O)CN=C(c2ccccc2)c3cc(ccc13)[N+]([O-])=O

InChI

1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChI key

GWUSZQUVEVMBPI-UHFFFAOYSA-N

General description

Nimetazepam, marketed as the benzodiazepine drug Erimin, is prescribed for the treatment of stress or short-term severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Cases of abuse have been reported from Southeast Asian countries including Thailand, Malaysia, Singapore, and Hong Kong to states such as Alabama and North Carolina. Although not used therapeutically in the US, the drug is known for its use to soften the comedown after use of methamphetamine or other stimulants.

Application


  • Advanced Analytical Techniques for Benzodiazepines: Nimetazepam has been included in studies using ultra-high performance liquid chromatography coupled with high-resolution time-of-flight mass spectrometry. This methodology is pivotal for the precise analysis of designer benzodiazepines and their pharmacokinetic properties, enhancing research in sedative biochemical studies and psychoactive drug research (Tomková et al., 2017).

  • Forensic and Clinical Toxicology: Development and validation of gas chromatography-mass spectrometry methods for benzodiazepine drugs, including nimetazepam, highlight its application in both clinical and forensic toxicology. This approach facilitates the accurate detection and quantification of benzodiazepines in biological specimens, aiding in the management of conditions such as sleep disorders and anxiety (Papoutsis et al., 2010).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K Schölermann et al.
Beitrage zur gerichtlichen Medizin, 48, 657-665 (1990-01-01)
The article describes analytical data for the screening and detection of nimetazepam and its major metabolites. The methods comprise thin-layer chromatography, gas chromatography, UV-spectrophotometry, infrared- and mass spectrometry.
T Yotsuyanagi et al.
Clinical and experimental dermatology, 23(3), 113-115 (1998-12-23)
The case is presented of a 34-year-old woman with rhabdomyolysis due to massive intake of nimetazepam, a benzodiazepine hypnotic. On admission, the patient had numerous blisters all over the body. One of the blisters in the gluteal region developed into
L H Peh et al.
Singapore medical journal, 30(1), 72-73 (1989-02-01)
Nimetazepam (Erimin) is a benzodiazepine which has become a new drug of abuse in Singapore. Three cases presenting with psychiatric complications had been treated as inpatients over a period of one and a half years (1986 to 1987) in Woodbridge
H Saito et al.
Research communications in chemical pathology and pharmacology, 46(3), 437-447 (1984-12-01)
This study was undertaken to evaluate fetal toxicity of benzodiazepine derivatives, nitrazepam, oxazepam, nimetazepam, clonazepam, diazepam and chlordiazepoxide. In fetotoxicities induced by the oral administration of these six drugs (100 mg/kg), nitrazepam (NTZ) and nimetazepam caused a great damage to
N Inotsume et al.
Journal of pharmaceutical sciences, 69(11), 1331-1334 (1980-11-01)
Hydrolytic reactions of nimetazepam and nitrazepam in acidic solutions at body temperature were studied spectrophotometrically. The open-ring compounds produced by hydrolysis were in equilibrium with the corresponding closed-ring compounds (protonated nimetazepam and nitrazepam). Forward-reaction rate constants of both drugs were

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