P-078

R-(-)-Phenylephrine hydrochloride solution

Name: R-(-)-Phenylephrine hydrochloride solution
Brand: CERILLIAN
Price: 105 USD

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

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1 ML

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₄ClNO₂

CAS Number:

61-76-7

Molecular Weight:

203.67

NACRES:

NA.24

UNSPSC Code:

41116107

EC Number:

200-659-6

Key Documents

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InChI key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

InChI

1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

SMILES string

Cl.CNC[C@H](O)c1cccc(O)c1

grade

certified reference material

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

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Show Differences

1 of 4

This Item	PHR1017	P1250000	BP284
Supelco P-078 R-(-)-Phenylephrine hydrochloride solution	Supelco PHR1017 Phenylephrine Hydrochloride	P1250000 Phenylephrine hydrochloride	BP284 Phenylephrine hydrochloride
application(s) forensics and toxicology	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) -
form liquid	form -	form -	form powder
Quality Level 300	Quality Level 300	Quality Level -	Quality Level -
grade certified reference material	grade certified reference material, pharmaceutical secondary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

General description

Phenylephrine, marketed as Neo-Synephrine^®, is the most common over-the-counter (OTC) decongestant in the US. Over the last few years, it has been marketed as a substitute for pseudoephedrine with tighter US government regulation of pseudoephedrine from the Combat Methamphetamine Epidemic Act of 2005.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Neo-Synephrine is a registered trademark of Bayer Healthcare LLC

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H370

pcodes

P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury.

Nai-jing Li et al.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 28(1), 1-6 (2013-03-27)

To investigate the effect of phenylephrine (an α-adrenergic agonist) on alveolar fluid clearance (AFC) in ventilator-induced lung injury and the possible mechanism involved. A total of 170 male Wistar rats were randomly allocated into 17 groups (n=10) using random number

Role of nitric oxide in optic nerve head blood flow regulation during isometric exercise in healthy humans.

Doreen Schmidl et al.

Investigative ophthalmology & visual science, 54(3), 1964-1970 (2013-02-27)

We determined whether administration of a nitric oxide synthase (NOS) inhibitor alters optic nerve head blood flow (ONHBF) regulation during isometric exercise in healthy subjects. Our study was done in a randomized, placebo-controlled, double-masked, three-way crossover design. A total of

Chemerin connects fat to arterial contraction.

Stephanie W Watts et al.

Arteriosclerosis, thrombosis, and vascular biology, 33(6), 1320-1328 (2013-04-06)

Obesity and hypertension are comorbid in epidemic proportion, yet their biological connection is largely a mystery. The peptide chemerin is a candidate for connecting fat deposits around the blood vessel (perivascular adipose tissue) to arterial contraction. We presently tested the

Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor.

Jin O-Uchi et al.

Biochemical and biophysical research communications, 433(2), 188-193 (2013-03-05)

Adrenoceptor stimulation is a key determinant of cardiac excitation-contraction coupling mainly through the activation of serine/threonine kinases. However, little is known about the role of protein tyrosine kinases (PTKs) activated by adrenergic signaling on cardiac excitation-contraction coupling. A cytoplasmic tyrosine

[Cardiovascular adverse effects due to phenylephrine eye drops in ophtalmic surgery].

S Kauffmann et al.

Annales francaises d'anesthesie et de reanimation, 32(2), 112-114 (2013-02-05)

Adverse systemic reactions such as cardiovascular effects may occur following topical ocular application of phenylephrine. We report the case of a 49-year-old woman who, following topical application of phenylephrine eyedrops, experienced hypertension with electrocardiographic modifications and a rise in cardiac

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