R-011

Supelco

Ritalinic acid hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Empirical Formula (Hill Notation):
C13H17NO2 · HCl
CAS Number:
Molecular Weight:
255.74
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

Featured Industry

Pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

Cl.OC(=O)C(C1CCCCN1)c2ccccc2

InChI

1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H

InChI key

SCUMDQFFZZGUQY-UHFFFAOYSA-N

General description

Ritalin®ic acid is a primary blood metabolite of methylphenidate, a psychostimulant sold under trade names Concerta® and Ritalin®. This Certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis. Methylphenidate is prescribed for treatment of attention-deficit hyperactivity disorder (ADHD), tachycardia, and narcolepsy.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation
Concerta is a registered trademark of ALZA Corporation
Ritalin is a registered trademark of Novartis Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Cerilliant Corporation

Signal Word

Danger

Target Organs

Eyes

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificate of Analysis
Certificate of Origin
Steve K Teo et al.
Journal of clinical pharmacology, 44(2), 173-178 (2004-01-30)
Attention deficit hyperactivity disorder (ADHD) in children is effectively treated by racemic oral methylphenidate (dl-MPH). The d-isomer (d-MPH) has been developed as an improved treatment for ADHD since only half the racemic dose is used. This study, performed in healthy...
D R Doerge et al.
Rapid communications in mass spectrometry : RCM, 14(8), 619-623 (2000-04-29)
Methylphenidate (MP, Ritalin) is a psychotropic drug widely prescribed to children for treating the symptoms of attention deficit disorder with and without hyperactivity. Because little information exists about the effects of chronic MP administration on cognitive function in children, measures...
Emilia Marchei et al.
Therapeutic drug monitoring, 32(4), 508-511 (2010-06-11)
The pharmacokinetics of methylphenidate (MPH), a prescription amphetamine derivative used in the treatment of attention-deficit hyperactivity disorder, has been amply described in conventional biological matrices. Recently, the excretion of MPH and its principal metabolite, ritalinic acid (RA) in oral fluid...
Mugimane G Manjanatha et al.
Environmental and molecular mutagenesis, 49(8), 585-593 (2008-07-12)
Methylphenidate hydrochloride (MPH) is one of the most frequently prescribed pediatric drugs for the treatment of attention deficit hyperactivity disorder. In a recent study, increased hepatic adenomas were observed in B6C3F1 mice treated with MPH in their diet. To evaluate...
Emilia Marchei et al.
Clinical chemistry, 56(4), 585-592 (2010-02-20)
We studied the excretion profile of methylphenidate (MPH) and its metabolite ritalinic acid (RA) in oral fluid and plasma, the oral fluid-to-plasma (OF/P) drug ratio, and the variations of oral fluid pH after drug administration. We analyzed oral fluid and...
Articles
As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid (2) is of clinical relevance.
Read More

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