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03-0146-00

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SMC® Amyloid Beta 42 High Sensitivity Kit

1 kit sufficient for 96 wells, input: serum, plasma, cerebrospinal fluid (CSF)

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Synonym(s):
Abeta 1-42 immunoassay kit, Abeta 42 Single Molecule Counting Kit, Abeta 42 immunoassay kit, Abeta 42 ultra-sensitive Immunoassay

Quality Level

usage

 kit sufficient for 96 wells

species reactivity

human, rat, mouse

manufacturer/tradename

SMC®

assay range

sensitivity: 0.98 pg/mL
(lower limit of quantification)

inter-assay cv: <20%
intra-assay cv: <15%
standard curve range: 0.24-250 pg/mL

technique(s)

ELISA: suitable
single molecule counting: suitable

input

serum
plasma
cerebrospinal fluid (CSF)

compatibility

for use with SMCxPRO® and Erenna<TMSYMBOL></TMSYMBOL> (validated)

shipped in

wet ice

storage temp.

2-8°C

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This Item
03-0145-0003-0160-0003-0188-00
species reactivity

human, rat, mouse

species reactivity

-

species reactivity

human

species reactivity

mouse, monkey, cat, rat

manufacturer/tradename

SMC®

manufacturer/tradename

SMC®

manufacturer/tradename

SMC®

manufacturer/tradename

SMC®

assay range

sensitivity: 0.98 pg/mL
(lower limit of quantification), inter-assay cv: <20%
intra-assay cv: <15%
standard curve range: 0.24-250 pg/mL

assay range

sensitivity: 5.86 pg/mL
(lower limit of quantification), inter-assay cv: <10%
intra-assay cv: <10%
(Intra-assay CV n=20; Inter-assay n=5)

assay range

sensitivity: 0.20 pg/mL
(lower limit of quantification), inter-assay cv: <20%
intra-assay cv: <15%
standard curve range: 0.05-50 pg/mL

assay range

sensitivity: 0.1 pg/mL
(Lower Limit of Quantification), inter-assay cv: 7%
intra-assay cv: 6%
(five normal plasma samples run in triplicate by 3 different operators on 3 different days.)

technique(s)

ELISA: suitable, single molecule counting: suitable

technique(s)

ELISA: suitable, single molecule counting: suitable

technique(s)

ELISA: suitable, single molecule counting: suitable

technique(s)

single molecule counting: suitable

input

serum
plasma
cerebrospinal fluid (CSF)

input

-

input

plasma
serum

input

-

General description

The SMC® Amyloid β1-42 High Sensitivity Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format.

Assay protocols are similar to existing sandwich ELISA methods with two key differences:
1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification.
2)The Erenna and SMCxPRO® immunoassay systems detect analytes using Single Molecule Counting (SMC®) technology.

Specificity

The capture antibody recognizes the C-terminal end of Amyloid beta 1-42, conferring specificity for Aβ42. No significant cross-reactivity to Aβ38 and Aβ40 was observed.

Legal Information

SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation

Target Organs

Respiratory Tract

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3


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Chia-Liang Tsai et al.
Journal of clinical medicine, 8(10) (2019-10-09)
Nondemented people with a family history of Alzheimer's disease (ADFH) and the ApoE-4 allele have been demonstrated to show a trend for a higher probability of cognitive decline and aberrant levels of cognitive-related biomarkers. However, the potential interactive effects on

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