03-0157-00

SMC^® Human IL-23 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human IL-23 in human serum and plasma

• Synonym(s): IL-23 Single Molecule Counting Kit, IL-23 ultra-sensitive immunoassay
• NACRES: NA.84
• UNSPSC Code: 12161503
• Species reactivity: human
• Technique(s): single molecule counting: suitable
• Usage: kit sufficient for 96 wells
• Compatibility: for use with FemtoQuest^™ and SMCxPRO^® instruments

Properties

• Product Name: SMC^® Human IL-23 High Sensitivity Immunoassay Kit,
• description: Used for ultrasensitive quantification of Human IL-23 in human serum and plasma
• product line: SMC^®
• usage: kit sufficient for 96 wells
• species reactivity: human
• technique(s): single molecule counting: suitable
• input: serum; plasma (K2 EDTA)
• UniProt accession no.: Q9NPF7
• compatibility: for use with FemtoQuest^™ and SMCxPRO^® instruments
• shipped in: wet ice
• storage temp.: 2-8°C

Description

General description

Interleukin-23 (IL-23) is a cytokine that plays a critical role in the immune system by promoting the differentiation and maintenance of Th17 cells, which are essential for the body′s defense against pathogens. It is composed of two subunits, p19 and p40, and is primarily produced by activated dendritic cells and macrophages. IL-23 is implicated in the pathogenesis of various inflammatory and autoimmune diseases, including psoriasis and inflammatory bowel disease, by driving chronic inflammation and sustaining the immune response.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease

Features and Benefits

• Remarkable Sensitivity: Leveraging SMC^®technology, this assay delivers unparalleled performance in measuring IL-23 levels in human serum and plasma, allowing for accurate quantification.
• Versatile Applications: The ultra-sensitive IL-23 immunoassay is suitable for various research applications, including biomarker discovery, therapeutic monitoring, and mechanistic studies of IL-23 in conditions such as psoriasis, Crohn′s disease, and other inflammatory disorders.
• Fast Results: With a streamlined workflow, the immunoassay delivers results quickly, allowing researchers to obtain timely data to drive their investigations forward.
• Compatibility with the FemtoQuest^™ System: This immunoassay is compatible with the FemtoQuest^™ system, enhancing its utility for researchers utilizing cutting-edge technology in their studies. This compatibility ensures optimal performance and ease of integration into existing workflows.

Packaging

96 well assay

Analysis Note

• Sensitivity: LLOQ 100 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 100-100,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 106% Plasma: 98%
• Recovery: Serum: 95% Plasma: 86%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although IL-23 was detectable in guinea pig, non-human primate, rat, rabbit and canine samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• hcodes: H302 + H332,H311,H319,H360FD,H412,EUH430
• pcodes: P201 - P202 - P273 - P280 - P308 + P313 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B