05-1117
Anti-VEGF Antibody, clone VG1
ascites fluid, clone VG1, from mouse
Synonym(s):
Vascular permeability factor, vascular endothelial growth factor, vascular endothelial growth factor A, vascular endothelial growth factor isoform VEGF165
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100 μL
$476.00
$476.00
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A recombinant, preservative-free antibody is available for your target. Try ZRB1320
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
clone
VG1, monoclonal
species reactivity
mouse, human, rat
technique(s)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
1 of 4
This Item | 05-1116 | AB1876-I | ABS82 |
|---|---|---|---|
| species reactivity mouse, human, rat | species reactivity human, rat | species reactivity rat, mouse | species reactivity mouse, rat, human |
| clone VG1, monoclonal | clone CH-10, monoclonal | clone polyclonal | clone polyclonal |
| antibody form ascites fluid | antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| biological source mouse | biological source mouse | biological source rabbit | biological source rabbit |
| technique(s) western blot: suitable | technique(s) western blot: suitable | technique(s) immunohistochemistry: suitable (paraffin), western blot: suitable | technique(s) immunohistochemistry: suitable (paraffin), western blot: suitable |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
General description
Approx. 12-28 kDa
VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines.
Immunogen
Recombinant human VEGF 189aa isoform
Application
Detect VEGF using this Anti-VEGF Antibody, clone VG1 validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Biochem/physiol Actions
Detects the 121, 165, and 189 amino acid isoforms of VEGF.
Physical form
Unpurified
Unpurified mouse monoclonal IgG1κ in ascites fluid containing no preservatives.
Preparation Note
Stable for 12 months at -20°C from date of receipt.
Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
NIH/3T3 cell lysate
NIH/3T3 cell lysate
Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected VEGF on 10 µg of NIH/3T3 cell lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected VEGF on 10 µg of NIH/3T3 cell lysate.
Other Notes
Replaces: MAB3734
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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