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05-23-0101

Sigma-Aldrich

Angiotensin II, Human

Plays an important role in the regulation of blood pressure.

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Synonym(s):
Angiotensin II, Human, DRVYIHPF, ang II
Empirical Formula (Hill Notation):
C50H71N13O12
CAS Number:
Molecular Weight:
1046.18

biological source

human

Quality Level

sterility

non-sterile

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

technique(s)

cell based assay: suitable

color

white to off-white

solubility

5% acetic acid: 1 mg/mL
water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

Gene Information

human ... ACE2(59272)

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This Item
A952505-23-0310A8846
Sigma-Aldrich

05-23-0101

Angiotensin II, Human

Angiotensin II human ≥93% (HPLC), powder

A9525

Angiotensin II human

assay

≥98% (HPLC)

assay

≥93% (HPLC)

assay

≥96% (HPLC)

assay

-

form

solid

form

powder

form

lyophilized solid

form

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

storage condition

OK to freeze, desiccated

storage condition

-

solubility

5% acetic acid: 1 mg/mL, water: 1 mg/mL

solubility

water: 25 mg/mL, clear, colorless

solubility

5% acetic acid: 1 mg/mL

solubility

-

shipped in

ambient

shipped in

-

shipped in

ambient

shipped in

-

General description

Research area: Cell signaling

Cell permeable: no

Primary Target adenylate cyclase activity

Product does not compete with ATP.

Reversible: no

Application

Angiotensin II, Human has been used to induce fibrosis in mice to evaluate the impact of fibroblast loss on cardiac function after injury. It has also been used to induce abdominal aortic aneurysm (AAA) progression in mice.

Biochem/physiol Actions

Angiotensin II is a crucial component of the Renin-Angiotensin System (RAS). It plays a vital role in vasoconstriction, regulating blood pressure, and controlling fluid balance by influencing the retention of sodium and water in the renal tubules. Furthermore, Angiotensin II stimulates the release of aldosterone from the adrenal gland, contributing to the maintenance of fluid and electrolyte balance regulation. Angiotensin II also promotes inflammation and tissue injury. It Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II also activates JAK2 in smooth muscle cells, as well as several kinases including p125FAK, cytosolic calcium-dependent tyrosine kinase, and p60c-src in various cell types. In vascular smooth muscle cells, it activates ERK1/2, JNK, and p38 MAP Kinase.

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Other Notes

Zhu, M., et al. 2000. J. Neurophysiol.84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Early Progression of Abdominal Aortic Aneurysm is Decelerated by Improved Endothelial Barrier Function via ALDH2-LIN28B-ELK3 Signaling
Yang K, et al.
Journal of Separation Science, 10(32) (2023)
Bo Lu et al.
Pharmaceutical biology, 59(1), 1045-1057 (2021-08-08)
HuoXue QianYang QuTan Recipe (HQQR) is used to manage hypertension and cardiac remodelling, but the mechanism is elusive. To determine the mechanism of HQQR on obesity hypertension (OBH)-related myocardial fibrosis. OBH models were prepared using spontaneously hypertensive rats (SHRs) and
Angiotensin II inhibits glomerular adenylate cyclase via the angiotensin II receptor subtype 1 (AT1)
Edwards R M and Stack E J
The Journal of Pharmacy and Pharmacology, 266(2), 506-510 (1993)
Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK
Eguchi S, et al.
The Journal of Biological Chemistry, 276(11), 7957-7962 (2001)
Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK
Eguchi S, et al.
The Journal of Biological Chemistry, 276(11), 7957-7962 (2001)

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