This product is not tested for cell culture use prior to release. Customers will need to validate each lot received if they plan to use it in cell culture.
05-23-0500
Bradykinin
Induces the release of nitric oxide.
Synonym(s):
Bradykinin, Kallidin, RPPGFSPFR, callidin
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1 MG
$27.70
5 MG
$85.10
25 MG
$214.00
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1 MG
$27.70
5 MG
$85.10
25 MG
$214.00
About This Item
Empirical Formula (Hill Notation):
C50H73N15O11
CAS Number:
Molecular Weight:
1060.21
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥97% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white to off-white
solubility
5% acetic acid: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N
InChI
1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
InChI key
QXZGBUJJYSLZLT-FDISYFBBSA-N
General description
Bradykinin, a nonapeptide, is produced in plasma under inflammatory conditions by cleavage of kininogen by kallikrein.[1] Bradykinin is involved in a number of physiological functions, including the release of nitric oxide, stimulation of pain receptors, induction of antimitogenic effects,[2] inhibition of cAMP accumulation, induction of smooth muscle contraction, and vasodilation, as well as in inflammation processes. Also involved in edema resulting from trauma or injury. Improves post-ischemic recovery of the heart via a nitric oxide-dependent mechanism.
Application
Bradykininhas been used in studying the changes in colonic afferent response tobradykinin.[3]
Biochem/physiol Actions
Cell permeable: no
Primary Target
Induces the release of nitric oxide
Induces the release of nitric oxide
Product does not compete with ATP.
Reversible: no
Packaging
Yes
Sequence
H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
Physical form
Supplied as an acetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Mombouli, J.V., and Vanhoutte, P.M. 1995. Am. J. Hypertens.8, 195.
Zhu, P., et al. 1995. Cardiovasc. Res.29, 658.
Bedarida, G.V., et al. 1994. Horm. Metab. Res. 26, 109.
Altiok, N., and Fredholm, B.B. 1993. Cell Signal. 5, 279.
Zhu, P., et al. 1995. Cardiovasc. Res.29, 658.
Bedarida, G.V., et al. 1994. Horm. Metab. Res. 26, 109.
Altiok, N., and Fredholm, B.B. 1993. Cell Signal. 5, 279.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
KV7 but not dual small and intermediate KCa channel openers inhibit the activation of colonic afferents by noxious stimuli
Charity N. Bhebhe, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 325(5), G436-G445 (2023)
Ch Golias et al.
Hippokratia, 11(3), 124-128 (2007-07-01)
The present review article regarding the kinin system-bradykinin is dealing with the biological effects of the abovementioned entity mediated by specific B1 and B2 receptors as well as with its clinical implications known nowadays. The activation of the kinin system-bradykinin
Charity N Bhebhe et al.
American journal of physiology. Gastrointestinal and liver physiology, 325(5), G436-G445 (2023-09-05)
In numerous subtypes of central and peripheral neurons, small and intermediate conductance Ca2+-activated K+ (SK and IK, respectively) channels are important regulators of neuronal excitability. Transcripts encoding SK channel subunits, as well as the closely related IK subunit, are coexpressed
Immune System, Pain and Analgesia
H.L. Rittner, et al.
Journal of Separation Science, 5, 407-427 (2008)
Kwun Nok Mimi Man et al.
eLife, 12 (2023-06-20)
The cellular mechanisms mediating norepinephrine (NE) functions in brain to result in behaviors are unknown. We identified the L-type Ca2+ channel (LTCC) CaV1.2 as a principal target for Gq-coupled α1-adrenergic receptors (ARs). α1AR signaling increased LTCC activity in hippocampal neurons.
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is this product suitable for cells culture use?
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Can you provide information on the solubility of bradykinin, CAS # 58-82-2; product number 05-23-0500 in water?
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The solubility of the substance in water is 1 milligram per milliliter, and it has the same solubility in 5% acetic acid.
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