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MilliporeSigma

05-725

Sigma-Aldrich

Anti-53BP1 Antibody, clone BP18

ascites fluid, clone BP18, Upstate®

Synonym(s):

Anti-Anti-53BP1, Anti-Anti-TDRD30, Anti-Anti-p202, Anti-Anti-p53BP1

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200 μL
$490.00

$490.00

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

BP18, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgM

NCBI accession no.

NM_005657.1

UniProt accession no.

Q12888

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TP53BP1(7158)
mouse ... Trp53Bp1(27223)

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05-72605-647WH0007158M1
Anti-53BP1 Antibody, clone BP18 ascites fluid, clone BP18, Upstate®

Sigma-Aldrich

05-725

Anti-53BP1 Antibody, clone BP18

Anti-53BP1 Antibody, clone BP13 clone BP13, Upstate®, from mouse

Sigma-Aldrich

05-726

Anti-53BP1 Antibody, clone BP13

Anti-Tyrosinase Antibody, clone T311 clone T311, Upstate®, from mouse

Sigma-Aldrich

05-647

Anti-Tyrosinase Antibody, clone T311

Monoclonal Anti-TP53BP1 antibody produced in mouse clone 1B9, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

WH0007158M1

Monoclonal Anti-TP53BP1 antibody produced in mouse

antibody form

ascites fluid

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified immunoglobulin

clone

BP18, monoclonal

clone

BP13, monoclonal

clone

T311, monoclonal

clone

1B9, monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

species reactivity

mouse, human

species reactivity

human

species reactivity

human

species reactivity

human

Gene Information

human ... TP53BP1(7158)
mouse ... Trp53Bp1(27223)

Gene Information

human ... TP53BP1(7158)

Gene Information

-

Gene Information

human ... TP53BP1(7158)

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

indirect ELISA: suitable

General description

~250kDa

Immunogen

Mix of three GST fusion proteins corresponding to residues 1-337, 338-671, and 1331-1664, respectively, of human 53BP1

Application

Detect 53BP1 with Anti-53BP1 Antibody, clone BP18 (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Biochem/physiol Actions

53BP1

Physical form

Ascites
mouse ascites IgM containing 0.05% sodium azide and 30% glycerol

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated by immunoblot on whole cell lysates from HeLa cells

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificates of Analysis (COA)

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Maria Pinkerneil et al.
Targeted oncology, 11(6), 783-798 (2016-06-03)
Targeting of class I histone deacetylases (HDACs) exerts antineoplastic actions in various cancer types by modulation of transcription, upregulation of tumor suppressors, induction of cell cycle arrest, replication stress and promotion of apoptosis. Class I HDACs are often deregulated in
Irene M Ward et al.
Molecular and cellular biology, 23(7), 2556-2563 (2003-03-18)
53BP1 is a p53 binding protein of unknown function that binds to the central DNA-binding domain of p53. It relocates to the sites of DNA strand breaks in response to DNA damage and is a putative substrate of the ataxia
Maria Pinkerneil et al.
Molecular cancer therapeutics, 15(2), 299-312 (2016-01-17)
Class I histone deacetylases HDAC1 and HDAC2 contribute to cell proliferation and are commonly upregulated in urothelial carcinoma. To evaluate whether specific inhibition of these enzymes might serve as an appropriate therapy for urothelial carcinoma, siRNA-mediated knockdown and specific pharmacologic
Maria Pinkerneil et al.
Methods in molecular biology (Clifton, N.J.), 1655, 289-317 (2017-09-11)
Mutations, dysregulation, and dysbalance of epigenetic regulators are especially frequent in urothelial carcinoma (UC) compared to other malignancies. Accordingly, targeting epigenetic regulators may provide a window of opportunity particularly in anticancer therapy of UC. In general, these epigenetic regulators comprise
I Rappold et al.
The Journal of cell biology, 153(3), 613-620 (2001-05-02)
The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of p53 and enhances p53-mediated transcriptional activation. 53BP1 contains two breast cancer susceptibility gene 1 COOH terminus (BRCT) motifs, which are present in several proteins involved in
View All Related Papers

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