06-237

Anti-Gsα Antibody

Name: Anti-Gsα Antibody
Brand: MM
Price: 578 USD

serum, Upstate^®

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50 μL

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ICC, IP, WB

Citations:

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, bovine

manufacturer/tradename

Upstate^®

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_000516.4, NM_001077488.1, NM_001077489.1, NM_001077490.1, NM_016592.2, NM_080425.2, NM_080426.2

UniProt accession no.

Q5JWF2

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GNAS(2778)

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This Item	SAB2500470	SAB2100941	HPA054694
Sigma-Aldrich 06-237 Anti-Gsα Antibody	Sigma-Aldrich SAB2500470 Anti-Glycophorin A antibody produced in goat	Sigma-Aldrich SAB2100941 Anti-GNAS antibody produced in rabbit	Sigma-Aldrich HPA054694 Anti-GTSF1L antibody produced in rabbit
species reactivity mouse, human, bovine	species reactivity human	species reactivity guinea pig, horse, dog, bovine, rat, mouse, human	species reactivity human
antibody form serum	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
biological source rabbit	biological source goat	biological source rabbit	biological source rabbit
Gene Information human ... GNAS(2778)	Gene Information human ... GYPA(2993)	Gene Information human ... GNAS(2778)	Gene Information human ... GTSF1L(149699)
technique(s) immunocytochemistry: suitable, western blot: suitable, immunoprecipitation (IP): suitable	technique(s) immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable	technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) immunohistochemistry: 1:1000-1:2500

General description

large isoform (52 kDa) and small isoform (45 kDa)

Immunogen

peptide corresponding to the c-terminus of bovine Gsα (RMHLRQYELL); this sequence is present in all three isoforms of human Gsα (Gsα1, Gsα2, and GsαXL)

Application

Anti-Gsα Antibody is an antibody against Gsα for use in IC, IP & WB.

Research Category
Signaling

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Biochem/physiol Actions

Recognizes the large and small forms of Gsα; does not cross-react with other G proteins.

Physical form

Protein A purified

Serum diluted 1:1 in PBS.

Preparation Note

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Widely expressed

routinely evaluated by immunoblot on rat brain microsomal preparation (Catalog #12-144)

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: AB1639

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Transmembrane adenylyl cyclase regulates amphibian sperm motility through protein kinase A activation.

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Disruption of lipid-raft localized Gαs/tubulin complexes by antidepressants: a unique feature of HDAC6 inhibitors, SSRI and tricyclic compounds.

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Parathyroid hormone signaling via G?s is selectively inhibited by an NH(2)-terminally truncated G?s: implications for pseudohypoparathyroidism.

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β-Arrestins function to mediate G protein-coupled receptor (GPCR) desensitization and internalization and to initiate G protein independent signaling of GPCRs. Elucidating how β-arrestin and G protein signal pathways coordinate with each other is important to fully understand GPCR signaling. Here

Ablation of the Stimulatory G Protein α-Subunit in Renal Proximal Tubules Leads to Parathyroid Hormone-Resistance With Increased Renal Cyp24a1 mRNA Abundance and Reduced Serum 1,25-Dihydroxyvitamin D.

Yan Zhu et al.

Endocrinology, 157(2), 497-507 (2015-12-17)

PTH regulates serum calcium, phosphate, and 1,25-dihydroxyvitamin D (1,25(OH)2D) levels by acting on bone and kidney. In renal proximal tubules (PTs), PTH inhibits reabsorption of phosphate and stimulates the synthesis of 1,25(OH)2D. The PTH receptor couples to multiple G proteins.

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