06-807

Anti-LAT Antibody

Name: Anti-LAT Antibody
Brand: MM
Price: 460 USD

Upstate^®, from rabbit

Synonym(s):

Anti-IMD52, Anti-pp36

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400 μG

$460.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Key Documents

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Product Name

Anti-LAT Antibody, Upstate^®, from rabbit

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

manufacturer/tradename

Upstate^®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_014387

UniProt accession no.

O43561

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... LAT(27040)
mouse ... Lat(16797)

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This Item	05-435	ABS217	SAB4501186
Sigma-Aldrich 06-807 Anti-LAT Antibody	Sigma-Aldrich 05-435 Anti-Lck Antibody, clone 3A5	Sigma-Aldrich ABS217 Anti-phospho-LAT Antibody	Sigma-Aldrich SAB4501186 Anti-LAT antibody produced in rabbit
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
species reactivity mouse, human	species reactivity mouse, human, rat	species reactivity human	species reactivity rat, human, mouse
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
clone polyclonal	clone 3A5, monoclonal	clone polyclonal	clone polyclonal
UniProt accession no. O43561	UniProt accession no. P06239	UniProt accession no. O43561	UniProt accession no. O43561
technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) western blot: suitable	technique(s) ELISA: 1:5000, western blot: 1:500-1:1000

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Protein A Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.

Protein A purified

Preparation Note

Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

36/38 kDa

Application

Research Sub Category
Immunoglobulins & Immunology

Anti-LAT Antibody detects level of LAT & has been published & validated for use in IP & WB.

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Recognizes both forms of LAT.

Immunogen

GST-tagged fusion protein corresponding to residues 31-233 of human LAT

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

routinely evaluated by immunoblot on RIPA lysates from Jurkat cells

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Assessment of caspase mediated degradation of linker for activation of T cells (LAT) at a single cell level.

Klossowicz, Mikolaj, et al.

Journal of Immunological Methods, 389, 9-17 (2013)

Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis.

S I Gringhuis, A Leow, E A Papendrecht-Van Der Voort, P H Remans, F C Breedveld, C L Verweij

Journal of immunology (Baltimore, Md. : 1950) (1950)

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

Wange, R L, et al.

The Journal of Biological Chemistry, 270, 18730-18733 (1995)

High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.

B S Wilson et al.

The Journal of cell biology, 154(3), 645-658 (2001-08-08)

In mast cells, cross-linking the high-affinity IgE receptor (Fc(epsilon)RI) initiates the Lyn-mediated phosphorylation of receptor ITAMs, forming phospho-ITAM binding sites for Syk. Previous immunogold labeling of membrane sheets showed that resting Fc(epsilon)RI colocalize loosely with Lyn, whereas cross-linked Fc(epsilon)RI redistribute

Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies.

T Harder et al.

The Journal of cell biology, 151(2), 199-208 (2000-10-19)

Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft membrane domains have been implicated to play a role in TCR signal transduction. Here, we studied the assembly of

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