07-178

Anti-Hox A9 Antibody

Upstate^®, from rabbit

• Synonym(s): Anti-ABD-B, Anti-HOX1, Anti-HOX1.7, Anti-HOX1G
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: mouse, human
• manufacturer/tradename: Upstate^®
• technique(s): electrophoretic mobility shift assay: suitable; immunocytochemistry: suitable; western blot: suitable
• isotype: IgG
• NCBI accession no.: NM_152739
• UniProt accession no.: P31269
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... HOXA9(3205)

Description

General description

HOXA9 is a transcription factor with a central role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a characteristic feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. Overexpression of Hoxa-9 markedly expands hematopoietic stem cells. HOXA9 expression changes dramatically with age - a uniformly low level of expression during early adulthood is replaced by a frequently very high expression in adults over sixty.

Specificity

Based on a BLAST search, the antibody will likely cross react with Newt, Coelacanth, Dog, Chicken, and Rat Hox A9; Antelope, Mouse and Guinea Pig Hox 1.7; Frog, human and Zebrafish Hox A-9B; and Kenyan Clawed Frog Hox B.1

Hox A9

Immunogen

GST fusion protein corresponding to residues 194-272 of mouse Hox A9

Application

Detect Hox A9 with Anti-Hox A9 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in EMSA, WB, ICC.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Quality

Routinely evaluated by immunoblot on whole cell lysates of Hoxa9 immortalized HF1 myeloid progenitor cells

Target description

36kDa

Physical form

Format: Purified

Protein A chromatography

Protein A purified immunoglobulin presented in 0.02M phosphate buffer, pH 7.6, 0.25M NaCl, and 0.1% Sodium Azide before the addition of glycerol to 30%.

Storage and Stability

2 years at -20°C

Analysis Note

Control
Hoxa9 immortalized HF1 cells

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2