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07-404

Sigma-Aldrich

Anti-PRMT1 Antibody

Upstate®, from rabbit

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Synonym(s):
Anti-ANM1, Anti-HCP1, Anti-HRMT1L2, Anti-IR1B4
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PRMT1(3276)

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Anti-PRMT1 Antibody Upstate®, from rabbit

07-404

Anti-PRMT1 Antibody

Anti-PRMT5 Antibody Upstate®, from rabbit

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Anti-PRMT5 Antibody

Anti-PRMT5 Antibody, clone 23C7 clone 23C7, from mouse

04-1460

Anti-PRMT5 Antibody, clone 23C7

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

mouse

species reactivity

mouse, human

species reactivity

mouse, human

species reactivity

human

species reactivity

mouse, chicken, bovine, human, canine, hamster, monkey, rat

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

technique(s)

western blot: suitable

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

western blot: suitable

technique(s)

immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 2 μg/mL using whole cell extract of 293T cells

Gene Information

human ... PRMT1(3276)

Gene Information

human ... PRMT5(10419)

Gene Information

human ... PRMT5(10419)

Gene Information

human ... PRMT1(3276)

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General description

The methylation of arginine is mediated by the Protein Arginine Methyl Transferase (PRMT) family of enzymes. These enzymes transfer the methyl group from S-adenosyl-Lmethionine to the guanidino nitrogen atoms of an arginine residue. Arginine methylation was found to be an important modification in signal transduction, transcription, RNA transport, and splicing. PRMT1, also known as HRMT1L2 and IR1B4, was isolated through its interaction with BTG1 and TIS21, proteins that are important in cell quiescence. PRMT1 is a 361 amino acid protein; its splicing variants differ at the N-terminus, giving rise to three isoforms of 343, 361, and 347 amino acids (variants 1, 2, and 3 respectively). Proteins involved in the metabolism of RNA are substrates for PRMT1, among them Sam68.

Specificity

PRMT1 doublet

Immunogen

Peptide corresponding to residues 298-318 of human protein arginine methyltransferase 1.

Application

Anti-PRMT1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of PRMT1 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histones

Quality

routinely evaluated by immunoblot in lysates from Jurkat and 3T3/A31, NIH 3T3, HeLa, and mouse ES cells

Target description

42-44 kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A purified

Storage and Stability

2 years at -20°C

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


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Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade.
Moningka, NC; Tsarova, T; Sasser, JM; Baylis, C
Nephrology, Dialysis, and Transplantation null
Regulation of the EBNA1 Epstein-Barr virus protein by serine phosphorylation and arginine methylation.
Shire, K; Kapoor, P; Jiang, K; Hing, MN; Sivachandran, N; Nguyen, T; Frappier, L
Journal of virology null
Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo.
Herrmann, F; Lee, J; Bedford, MT; Fackelmayer, FO
The Journal of Biological Chemistry null
SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1.
Wagner, S; Weber, S; Kleinschmidt, MA; Nagata, K; Bauer, UM
The Journal of Biological Chemistry null
Arginine methylation of scaffold attachment factor A by heterogeneous nuclear ribonucleoprotein particle-associated PRMT1.
Herrmann, F; Bossert, M; Schwander, A; Akgun, E; Fackelmayer, FO
The Journal of Biological Chemistry null

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