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07-413

Sigma-Aldrich

Anti-dimethyl-Arginine Antibody, symmetric (SYM11)

Upstate®, from rabbit

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eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

shipped in

dry ice

target post-translational modification

unmodified

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This Item
07-41207-41409-814
antibody form

purified antibody

antibody form

serum

antibody form

serum

antibody form

serum

species reactivity

human, mouse

species reactivity

mouse, human

species reactivity

human, mouse

species reactivity

mouse

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

technique(s)

western blot: suitable

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

western blot: suitable

technique(s)

western blot: suitable

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General description

Symmetrical dimethylated arginine (sDMA) is a product of the post-translational modification, arginine methylation. sDMA is a structural isomer of asymmetric dimethylarginine.

Specificity

SmD3 at ~16kDa, and other proteins that contain arginines that are symmetrically dimethylated

Immunogen

peptide corresponding to amino acids 99-119 of Small nuclear ribonucleoprotein SmD3.

Application

Anti-dimethyl-Arginine Antibody, symmetric (SYM11) has been used in:
  • co-immunoprecipitation (co-IP)
  • western blot analysis
  • immunoprecipitation

Biochem/physiol Actions

Symmetrical dimethylarginine (sDMA) is a competitor of arginine transport and is eliminated through renal excretion. sDMA serves as a marker to indicate the estimated glomerular filtration rate (GFR) and the coronary artery disease (CAD) severity. Elevated sDMA is associated with the risk of cardiovascular disease and mortality. It might also help in the early detection of chronic kidney disease. sDMA acts as an endogenous marker of renal function. It is associated with tumorigenesis.

Quality

routinely evaluated by immunoblot in RIPA lysates from Jurkat cells

Target description

~16 kDa

Physical form

Format: Purified

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


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Jérémy Dufourt et al.
Nature communications, 8(1), 1305-1305 (2017-11-05)
Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine (Aub). Aub targets
Christopher R Smith et al.
Journal of medicinal chemistry, 65(3), 1749-1766 (2022-01-19)
The PRMT5•MTA complex has recently emerged as a new synthetically lethal drug target for the treatment of MTAP-deleted cancers. Here, we report the discovery of development candidate MRTX1719. MRTX1719 is a potent and selective binder to the PRMT5•MTA complex and
Ming Gao et al.
EMBO reports, 16(3), 379-386 (2015-01-21)
Germ cells give rise to all cell lineages in the next-generation and are responsible for the continuity of life. In a variety of organisms, germ cells and stem cells contain large ribonucleoprotein granules. Although these particles were discovered more than
Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.
Deng, X; Gu, L; Liu, C; Lu, T; Lu, F; Lu, Z; Cui, P; Pei, Y; Wang, B; Hu, S; Cao, X
Proceedings of the National Academy of Sciences of the USA null
Hao Yang et al.
Oncotarget, 7(44), 72131-72147 (2016-10-07)
Although cancer cells are known to be "addicted" to glucose, the effect of glucose in proliferation of these cells remains elusive. Here, we report that upon glucose induction, protein arginine methyltransferase 5 (PRMT5) exerts a profound effect on the G1-S

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