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MilliporeSigma

1.00160

Boric acid

crystalline, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF, ChP

Synonym(s):

Orthoboric acid, Trihydroxidoboron

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1 KG

$88.90

5 KG

$198.00

25 KG

$650.00

50 KG

$1,270.00

$88.90


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About This Item

Linear Formula:
H3BO3
CAS Number:
Molecular Weight:
61.83
MDL number:
UNSPSC Code:
12352301
EC Index Number:
233-139-2

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agency

BP
ChP
JP
NF
Ph. Eur.

Quality Level

vapor pressure

2.6 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

assay

99.5-100.5% dry basis (alkalimetric)

form

crystalline
solid

technique(s)

API processing | cocrystal formation: suitable
API processing | salt formation: suitable

pH

3.8-4.8 (20 °C, 33 g/L in H2O)

mp

160 °C (dec.) (lit.)

solubility

49.2 g/L

density

1.489 g/cm3 at 23 °C

anion traces

sulfate (SO42-): ≤0.04%

cation traces

As: ≤0.0001%
heavy metals (as Pb): ≤0.0015%

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

storage temp.

2-30°C

SMILES string

OB(O)O

InChI

1S/BH3O3/c2-1(3)4/h2-4H

InChI key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

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1 of 4

This Item
1.001621076341PHR2664
application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

technique(s)

API processing | cocrystal formation: suitable, API processing | salt formation: suitable

technique(s)

-

technique(s)

-

technique(s)

-

agency

BP, NF, JP, Ph. Eur.

agency

BP, JP, NF, Ph. Eur.

agency

-

agency

traceable to NIST NIST951A, traceable to NIST NIST973, traceable to USP 1076341

form

crystalline, solid

form

powder, solid

form

solid

form

powder

assay

99.5-100.5% dry basis (alkalimetric)

assay

99.5-100.5% dry basis (alkalimetric)

assay

-

assay

-

product line

EMPROVE® ESSENTIAL

product line

EMPROVE® ESSENTIAL

product line

-

product line

-

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Boric acid has antimicrobial characteristics and is therefore typically used as preservative in pharmaceutical formulations and cosmetics. It is also used as buffering agent and pH adjuster.

Preparation Note

Must be subjected to further processing during the preparation of injectable dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Articles

Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

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