101500
AEBSF, Hydrochloride
AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.
Synonym(s):
AEBSF, Hydrochloride
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 mg | Check Cart for Availability | $94.10 | |
| 100 mg | Check Cart for Availability | $144.00 | |
| 500 mg | Check Cart for Availability | $557.00 | |
| 1 g | Check Cart for Availability | $987.00 |
About This Item
Empirical Formula (Hill Notation):
C8H10FNO2S · xHCl
CAS Number:
Molecular Weight:
203.23 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
$94.10
Check Cart for Availability
Quality Level
assay
>97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white to off-white
solubility
water: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
F[S](=O)(=O)c1ccc(cc1)CCN.[Cl-].[H+]
InChI
1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChI key
WRDABNWSWOHGMS-UHFFFAOYSA-N
General description
AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.
Specific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K.
Specific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) . A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436).
Biochem/physiol Actions
Primary Target
chymotrypsin
chymotrypsin
Product does not compete with ATP.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
Other Notes
Citron, M., et al. 1996. Neuron 17, 171.
Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
Mintz, G.R. 1993. BioPharm. 6, 34.
Lawson, W.B., et al. 1982. Folia Haematol.109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.
Markwardt, F., et al. 1973. Thromb. Res.2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.
Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
Mintz, G.R. 1993. BioPharm. 6, 34.
Lawson, W.B., et al. 1982. Folia Haematol.109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.
Markwardt, F., et al. 1973. Thromb. Res.2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
1 of 1
This Item | |||
|---|---|---|---|
| assay >97% (HPLC) | assay ≥99% (HPLC) | assay ≥98% (HPLC) | assay ≥97% |
| form solid | form powder | form solid | form liquid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility water: 25 mg/mL | solubility H2O: 50 mg/mL | solubility 10 g/L | solubility - |
Still not finding the right product?
Explore all of our products under AEBSF, Hydrochloride
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1A
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Articles
YeastBuster™ Protein Extraction Reagent for Fast, Efficient Extraction of Proteins from Yeast
Related Content
Natarajan V Bhanu et al.
Bio-protocol, 10(18), e3756-e3756 (2021-03-05)
Chromatin modifications, like histone post translational modifications (PTMs), are critical for tuning gene expression and many other aspects of cell phenotype. Liquid chromatography coupled to mass spectrometry (LC-MS) has become the most suitable method to analyze histones and histone PTMs
Michael C Yoon et al.
Biochemistry, 62(15), 2289-2300 (2023-07-17)
The biological and pathological functions of cathepsin B occur in acidic lysosomes and at the neutral pH of cytosol, nuclei, and extracellular locations. Importantly, cathepsin B displays different substrate cleavage properties at acidic pH compared to neutral pH conditions. It
Ziyi Liu et al.
Methods and protocols, 7(1) (2024-02-23)
The development of monoclonal antibodies (mAbs) represents a significant milestone in both basic research and clinical applications due to their target specificity and versatility in therapeutic and diagnostic applications. The innovative strategy of mAb screening, utilizing phage display, facilitates the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 101500-100MG | 04055977226317 |
| 101500-50MG | 04055977226331 |
| 101500-5GM | 04055977226324 |
| 101500-500MG | 04055977226348 |
| 101500-6GM | 04055977226355 |
| 101500-1GM | 04055977226300 |