1.01566

L-Asparagine monohydrate

for biochemistry

• Synonym(s): L-Asparagine monohydrate, Asparaginic acid semiamide, Asn
• Empirical Formula (Hill Notation): C₄H₈N₂O₃ · xH₂O
• CAS Number: 5794-13-8
• Molecular Weight: 132.12 (anhydrous basis)
• MDL number: MFCD00151038
• UNSPSC Code: 12352209
• EC Index Number: 200-735-9
• NACRES: NA.21

Properties

• Quality Level: 100
• form: solid
• pH: 4.0-5.5 (20 °C, 20 g/L in H₂O)
• mp: 215-217 °C (decomposes)
• solubility: 22 g/L
• bulk density: 530 kg/m³
• storage temp.: 2-30°C
• SMILES string: [N+H3][C@@H](CC(=O)N)C(=O)[O-].O
• InChI: 1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1
• InChI key: RBMGJIZCEWRQES-DKWTVANSSA-N

Description

Application

• Chiral Resolution and Amino Acid Racemase Applications: L-Asparagine monohydrate has been utilized in the immobilization of amino acid racemases complemented with preferential crystallization process for enhanced chiral resolutions (Carneiro et al., 2020).


• Electro-optical Property Studies: L-Asparagine monohydrate can be used to prepare growth crystals to study its electro-optical properties, particularly in noncentrosymmetric crystal environments. (Shkir et al., 2015).

Analysis Note

• Assay (perchloric acid titration, calculated on dried substance): 99.0 - 101.0 %
• Identity (IR-spectrum): passes test
• Identity (specific rotation): passes test
• Appearance: white to almost white crystalline powder or colorless crystals
• Appearance of solution (20 g/l, CO₂-free water): clear and colorless
• Spec. rotation (α 20/D, 100 g/l, hydrochloric acid 3 mol/l, calc. on dried substance): +33.7 to +36.0
• Chloride (Cl): ≤ 50 ppm
• Sulfate (SO₄): ≤ 50 ppm
• As (Arsenic): ≤ 5 ppm
• Ca (Calcium): ≤ 10 ppm
• Co (Cobalt): ≤ 5 ppm
• Fe (Iron): ≤ 5 ppm
• K (Potassium): ≤ 5 ppm
• Mg (Magnesium): ≤ 5 ppm
• Na (Sodium): ≤ 50 ppm
• Pb (Lead): ≤ 10 ppm
• Zn (Zinc): ≤ 5 ppm
• Ninhydrin-positive substances (LC)(Aspartic acid): ≤ 0.5 %
• Ninhydrin-positive substances (LC)(any other ninhydrin-positive impurity): ≤ 0.3 %
• Ninhydrin-positive substances (LC) (ammonium (570 nm)): ≤ 0.02 %
• Ninhydrin-positive substances (LC)(total impurities): ≤ 0.8 %
• Loss on drying (130 °C, 3 h): 10.5 - 12.5 %

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable