1.02695

Benzyl alcohol

for headspace gas chromatography SupraSolv^®

• Synonym(s): Benzenemethanol
• Linear Formula: C₆H₅CH₂OH
• CAS Number: 100-51-6
• Molecular Weight: 108.14
• UNSPSC Code: 41116105
• NACRES: NA.03
• EC Index Number: 202-859-9
• MDL number: MFCD00004599
• Beilstein/REAXYS Number: 878307
• Assay: ≥99.5% (GC)
• Technique(s): GC-HS: suitable
• Bp: 203-205 °C (lit.)
• Vapor pressure: 0.07 hPa ( 20 °C), 13.3 mmHg ( 100 °C), 3.75 mmHg ( 77 °C)

Properties

• Quality Segment: 100
• agency: according to Ph. Eur., according to USP
• vapor density: 3.7 (vs air)
• vapor pressure: 0.07 hPa ( 20 °C), 13.3 mmHg ( 100 °C), 3.75 mmHg ( 77 °C)
• product line: SupraSolv^®
• assay: ≥99.5% (GC)
• form: liquid
• autoignition temp.: 435 °C, 817 °F
• technique(s): GC-HS: suitable
• impurities: ≤0.001 meq/g Acidity, ≤0.002 meq/g Alkalinity, ≤0.1% Water, ≤1 μg/g Every residual solvent of class 1 acc. to ICH, ≤10 μg/g Every residual solvent of class 2 acc. to ICH, ≤50 μg/g Every residual solvent of class 3 acc. to ICH
• color: APHA: ≤10
• refractive index: n20/D 1.539 (lit.)
• bp: 203-205 °C (lit.)
• mp: −16-−13 °C (lit.)
• transition temp: flash point 101 °C
• density: 1.045 g/mL at 25 °C (lit.)
• storage temp.: 2-30°C
• SMILES string: OCc1ccccc1
• InChI: 1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
• InChI key: WVDDGKGOMKODPV-UHFFFAOYSA-N

Description

General description

SupraSolv^® for headspace gas chromatography (GC-HS) is a dedicated high-purity solvent grade specifically formulated to meet the stringent analytical demands of residual solvent determination in pharmaceutical active pharmaceutical ingredients (APIs), drug products, and other regulated matrices.In headspace GC, the solvent serves as the diluent medium in which the sample is dissolved prior to equilibrium partitioning of volatile analytes into the gaseous headspace phase for subsequent chromatographic injection. Consequently, the chemical purity of the solvent is of critical analytical importance: any residual volatile impurities intrinsic to the solvent matrix may co-elute with target analytes, generating false-positive signals or suppressing accurate quantification. SupraSolv^® headspace solvents are therefore specifically developed and tested to contain extremely low concentrations of residual solvents, as mandated by regulatory guidelines.

Application

SupraSolv^® headspace GC solvents are indispensable in pharmaceutical residual solvent testing, polymer and excipient quality control, food packaging safety assessment, and industrial material characterization — analytical contexts in which solvent purity is a direct regulatory and safety requirement, and where the integrity of trace-level volatile quantification is non-negotiable.

Features and Benefits

• Regulatory compliance with ICH Q3C, Ph. Eur., and USP residual solvent guidelines, directly supporting pharmaceutical quality control workflows
• Ultra-low intrinsic volatile impurity content, eliminating solvent-derived interferences in the headspace chromatogram and ensuring an unobstructed baseline
• Batch-to-batch consistency, ensuring reproducibility across analytical campaigns

Analysis Note

SupraSolv^® headspace solvents adhere to the residual solvent classification thresholds defined by the International Council for Harmonisation (ICH Q3C) and referenced in pharmacopoeial standards (Ph. Eur. and USP), with certified limits including:

• Class 1 solvents (known human carcinogens / environmental hazards): ≤ 1 µg/g
• Class 2 solvents (non-genotoxic, dose-dependent toxicants): ≤ 10 µg/g
• Class 3 solvents (low toxic potential): ≤ 50 µg/gThese specifications are verified lot-by-lot via GC/HS analysis, providing robust certification of compliance and analytical traceability.

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS07
• signalword: Warning
• Storage Class: 10 - Combustible liquids
• flash_point_f: 213.8 °F - DIN 51758
• flash_point_c: 101 °C - DIN 51758
• hcodes: H302 + H332,H317,H319
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1B