1.06018

Methanol

for liquid chromatography LiChrosolv^®

• Synonym(s): MeOH, Hydroxymethane, Carbinol, Methyl alcohol
• Linear Formula: CH₃OH
• CAS Number: 67-56-1
• Molecular Weight: 32.04
• Beilstein: 1098229
• MDL number: MFCD00004595
• EC Index Number: 200-659-6

Properties

• grade: HPLC grade; isocratic
• Quality Level: 100
• vapor density: 1.11 (vs air)
• vapor pressure: 128 hPa ( 20 °C); 410 mmHg ( 50 °C); 97.68 mmHg ( 20 °C)
• product line: LiChrosolv^®
• Assay: ≥99.8% (GC)
• form: liquid
• autoignition temp.: 725 °F
• potency: 5628 mg/kg LD₅₀, oral (Rat); 17100 mg/kg LD₅₀, skin (Rabbit)
• expl. lim.: 36 %
• technique(s): HPLC: suitable
• impurities: ≤0.0002 meq/g Acidity; ≤0.0002 meq/g Alkalinity; ≤0.03% Water
• evapn. residue: ≤3.0 mg/L
• color: APHA: ≤10
• transmittance: 225 nm, ≥50%; 240 nm, ≥80%; 265 nm, ≥98%
• refractive index: n20/D 1.329 (lit.)
• kinematic viscosity: 0.54-0.59 cSt(20 °C)
• bp: 64.7 °C (lit.)
• mp: −98 °C (lit.)
• transition temp: flash point 9.7 °C
• density: 0.791 g/mL at 25 °C (lit.)
• format: neat
• storage temp.: 2-30°C
• SMILES string: CO
• InChI: 1S/CH4O/c1-2/h2H,1H3
• InChI key: OKKJLVBELUTLKV-UHFFFAOYSA-N

Description

General description

LiChrosolv^® solvents exhibit high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level. This makes them ideal for reproducible separations.

Application

Intended for HPLC and UHPLC-MS applications.
Featured in method development of:

• Benazepril - USP Method Benazepril RS
• Betamethasone - USP Method Betamethasone Valerate Assay
• Irbesartan - USP Method Irbesartan Assay
• Lamivudine - USP Method Lamivudine RS
• Lansoprazole - USP Method Lansoprazole RS
• Levofloxacin - USP Method Levofloxacin RS - USP Method Levofloxacin Assay
• Nifedipine - USP Method Nifedipine RS - USP Method Nifedipine Assay
• Pharmacopoeia Monograph Methods - HPLC and UHPLC methods for Regulated Drug Analysis
• Pioglitazone - USP Method Pioglitazone HCl RS - USP Method Pioglitazone HCl Assay

Features and Benefits

• suitability tested and specified for UHPLC-MS and UHPLC-UV: for analytical flexibility
• specified quality in positive and negative in positive and negative electrospray ionization (ESI) and atmospheric-pressure chemical ionization-mass spectrometry (APCI-MS) for lowest detection limits and confidence in analyses for all important MS modes (test 1)
  —ESI/APCI (+) < 2 ppb
  —ESI/APCI (-) < 10 ppb
• lowest impurity profile: for interference-free baselines (test 2)
• microfiltered through 0.2 μm filter (test 3) to provide:
  —A long lifespan to filters and mechanical parts of HPLC systems
  ––reduced risk of column clogging
• packaged in borosilicate glass bottles for minimized metal ion contaminations
• lowest levels of trace metal impurities for a minimum metal ion adduct formation
  —<5 ppb
• lowest level of polyethylene glycol (PEG) impurities in UHPLC-MS solvent lineup (PEG S/N signal-to-noise-ratio < 50)

Preparation Note

Product filtered through a 0.2 μm filter

Analysis Note

Evaporation Number: 1.9

Purity (GC): ≥ 99.8 %
Identity (IR): conforms
Evaporation residue: ≤ 3.0 mg/l
Water: ≤ 0.03 %
Color: ≤ 10 Hazen
Acidity: ≤ 0.0002 meq/g
Alkalinity: ≤ 0.0002 meq/g
Transmission (at 225 nm): ≥ 50 %
Transmission (at 240 nm): ≥ 80 %
Transmission (from 265 nm): ≥ 98 %
Filtered by 0.2 µm filter

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H301 + H311 + H331 - H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup